Abstract
Background: The aim of this study was to compare plasma fibrinogen levels in hypertensive and normotensive men. Possible confounding factors, such as age, cholesterol levels, body-mass index and smoking habits were also to be considered. Methods: We studied 708 men with essential hypertension (according to the World Health Organization’s criteria) and 944 with normal blood pressures, all of whom had similar lifestyles; the overall age range was 18-60 years. The clinical evaluation included measurements of blood pressure, heart rate, body weight and height as well as a medical examination and personal habits history. After an overnight fast, blood samples were taken in order to measure fibrinogen and total-cholesterol levels. Results: The mean fibrinogen level did not differ between the groups, although the distribution of the levels was different and was J-shaped in the hypertensive group. Plasma fibrinogen levels increased significantly with age in both groups. A significant positive correlation was found between fibrinogen and total-cholesterol levels, but not between fibrinogen and body-mass index or systolic or diastolic blood pressures. Cigarette smokers had significantly higher fibrinogen levels than non-smokers, irrespective of their blood pressure status; ex-smokers had intermediate values, suggesting a direct but reversible effect of tobacco. In cigarette smokers, fibrinogen levels increased with the number of cigarettes smoked, which is indicative of a dose-response relationship. Conclusion: This study confirms the strong association between fibrinogen levels and smoking and the weaker association with age and total-cholesterol levels. Mean fibrinogen level was not significantly related to blood pressure, although the distribution of fibrinogen levels appeared to be J-shaped in hypertensive men.
| Original language | English |
|---|---|
| Pages (from-to) | 149-153 |
| Number of pages | 5 |
| Journal | Journal of Cardiovascular Risk |
| Volume | 1 |
| Issue number | 2 |
| Publication status | Published - 1994 |
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Keywords
- Cholesterol
- Fibrinogen
- Hypertension
- Smoking
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Fibrinogen levels in normotensive and hypertensive men : A cross-sectional study. / Fogari, Roberto; Zoppi, Annalisa; Tettamanti, Franco; Malamani, Gian Domenico; Marasi, Gianluigi; Vanasia, Alessandro; Villa, Gianmarco.
In: Journal of Cardiovascular Risk, Vol. 1, No. 2, 1994, p. 149-153.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fibrinogen levels in normotensive and hypertensive men
T2 - A cross-sectional study
AU - Fogari, Roberto
AU - Zoppi, Annalisa
AU - Tettamanti, Franco
AU - Malamani, Gian Domenico
AU - Marasi, Gianluigi
AU - Vanasia, Alessandro
AU - Villa, Gianmarco
PY - 1994
Y1 - 1994
N2 - Background: The aim of this study was to compare plasma fibrinogen levels in hypertensive and normotensive men. Possible confounding factors, such as age, cholesterol levels, body-mass index and smoking habits were also to be considered. Methods: We studied 708 men with essential hypertension (according to the World Health Organization’s criteria) and 944 with normal blood pressures, all of whom had similar lifestyles; the overall age range was 18-60 years. The clinical evaluation included measurements of blood pressure, heart rate, body weight and height as well as a medical examination and personal habits history. After an overnight fast, blood samples were taken in order to measure fibrinogen and total-cholesterol levels. Results: The mean fibrinogen level did not differ between the groups, although the distribution of the levels was different and was J-shaped in the hypertensive group. Plasma fibrinogen levels increased significantly with age in both groups. A significant positive correlation was found between fibrinogen and total-cholesterol levels, but not between fibrinogen and body-mass index or systolic or diastolic blood pressures. Cigarette smokers had significantly higher fibrinogen levels than non-smokers, irrespective of their blood pressure status; ex-smokers had intermediate values, suggesting a direct but reversible effect of tobacco. In cigarette smokers, fibrinogen levels increased with the number of cigarettes smoked, which is indicative of a dose-response relationship. Conclusion: This study confirms the strong association between fibrinogen levels and smoking and the weaker association with age and total-cholesterol levels. Mean fibrinogen level was not significantly related to blood pressure, although the distribution of fibrinogen levels appeared to be J-shaped in hypertensive men.
AB - Background: The aim of this study was to compare plasma fibrinogen levels in hypertensive and normotensive men. Possible confounding factors, such as age, cholesterol levels, body-mass index and smoking habits were also to be considered. Methods: We studied 708 men with essential hypertension (according to the World Health Organization’s criteria) and 944 with normal blood pressures, all of whom had similar lifestyles; the overall age range was 18-60 years. The clinical evaluation included measurements of blood pressure, heart rate, body weight and height as well as a medical examination and personal habits history. After an overnight fast, blood samples were taken in order to measure fibrinogen and total-cholesterol levels. Results: The mean fibrinogen level did not differ between the groups, although the distribution of the levels was different and was J-shaped in the hypertensive group. Plasma fibrinogen levels increased significantly with age in both groups. A significant positive correlation was found between fibrinogen and total-cholesterol levels, but not between fibrinogen and body-mass index or systolic or diastolic blood pressures. Cigarette smokers had significantly higher fibrinogen levels than non-smokers, irrespective of their blood pressure status; ex-smokers had intermediate values, suggesting a direct but reversible effect of tobacco. In cigarette smokers, fibrinogen levels increased with the number of cigarettes smoked, which is indicative of a dose-response relationship. Conclusion: This study confirms the strong association between fibrinogen levels and smoking and the weaker association with age and total-cholesterol levels. Mean fibrinogen level was not significantly related to blood pressure, although the distribution of fibrinogen levels appeared to be J-shaped in hypertensive men.
KW - Cholesterol
KW - Fibrinogen
KW - Hypertension
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=0028490519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028490519&partnerID=8YFLogxK
M3 - Article
VL - 1
SP - 149
EP - 153
JO - Journal of Cardiovascular Risk
JF - Journal of Cardiovascular Risk
SN - 1350-6277
IS - 2
ER -