Fibrinogen plasma levels in an apparently healthy general population: Relation to environmental and genetic determinants

Maurizio Margaglione, Giuseppe Cappucci, Donatella Colaizzo, Leonardo Pirro, Gennaro Vecchione, Elvira Grandone, Giovanni Di Minno

Research output: Contribution to journalArticle

Abstract

Elevated fibrinogen levels are an independent risk factor for cardiovascular ischemic disease. We investigated the relationship between cardiovascular ischemic risk factors, the fibrinogen Bβ-chain G/A-455 polymorphism and plasma fibrinogen levels in 989 apparently healthy subjects. Fibrinogen values were higher in subjects with C reactive protein (C-RP) > 0.33 mg/dl, BMI > 23.9 kg/m2, total cholesterol > 4.84 mmol/l, triglycerides > 1.02 mmol/l, PAI-1 antigen > 12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming > 10 cigarettes per day (p <0.01). Men and ethanol drinkers showed lower plasma fibrinogen levels (p <0.01). The multivariate analysis confirmed the independent effect of C-RP, age, BMI, total cholesterol, gender, PAI-1, -455 G/A polymorphism, (p <0.05). BMI, total cholesterol, PAI-1, alcohol and smoking habit raised with the increase of age and differed between sexes. The A-455 allele increasing effect was significant in women, especially in subjects aged <30 years, and in men aged <43 years. These results indicate that environmental factors contributed to a larger extent to fibrinogen variability, whereas the A-455 allele was associated with a steeper increase in younger age quartiles.

Original languageEnglish
Pages (from-to)805-810
Number of pages6
JournalThrombosis and Haemostasis
Volume80
Issue number5
Publication statusPublished - Nov 1998

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Fibrinogen
Plasminogen Activator Inhibitor 1
Population
Alleles
Cholesterol
C-Reactive Protein
Tobacco Products
Habits
Coronary Artery Disease
Healthy Volunteers
Triglycerides
Ethanol
Cardiovascular Diseases
Multivariate Analysis
Smoking
Alcohols
Antigens

ASJC Scopus subject areas

  • Hematology

Cite this

Fibrinogen plasma levels in an apparently healthy general population : Relation to environmental and genetic determinants. / Margaglione, Maurizio; Cappucci, Giuseppe; Colaizzo, Donatella; Pirro, Leonardo; Vecchione, Gennaro; Grandone, Elvira; Di Minno, Giovanni.

In: Thrombosis and Haemostasis, Vol. 80, No. 5, 11.1998, p. 805-810.

Research output: Contribution to journalArticle

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