Abstract
The aim of this study was to evaluate the effects of imidapril and candesartan on fibrinolysis and insulin sensitivity in normoweight hypertensive patients. After a 2-week wash-out period, 61 patients with mild-to-moderate hypertension were randomized to imidapril or candesartan for 12 weeks. Blood pressure (BP), plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen activities were evaluated at baseline and during treatment. The patients underwent a euglycemic-hyperinsulinemic clamp (insulin sensitivity was evaluated as glucose infusion rate during the last 30 min) and a desmopressin test (with desmopressin infusion in the brachial artery) to evaluate endothelial ability to release t-PA. Imidapril and candesartan induced similar systolic/diastolic BP reductions (16/12.6 and 16.1/12.2 mm Hg, respectively, P-1 per kg, P-1, P-1) than by candesartan (2.73 IU ml -1, P
Original language | English |
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Pages (from-to) | 509-515 |
Number of pages | 7 |
Journal | Hypertension Research |
Volume | 34 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2011 |
Keywords
- candesartan
- fibrinolysis
- imidapril
- insulin sensitivity
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine