Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension

Roberto Fogari, Annalisa Zoppi, Sibilla A T Salvadeo, Amedeo Mugellini, Pierangelo Lazzari, Tara Santoro, Giuseppe Derosa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of this study was to evaluate the effects of imidapril and candesartan on fibrinolysis and insulin sensitivity in normoweight hypertensive patients. After a 2-week wash-out period, 61 patients with mild-to-moderate hypertension were randomized to imidapril or candesartan for 12 weeks. Blood pressure (BP), plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen activities were evaluated at baseline and during treatment. The patients underwent a euglycemic-hyperinsulinemic clamp (insulin sensitivity was evaluated as glucose infusion rate during the last 30 min) and a desmopressin test (with desmopressin infusion in the brachial artery) to evaluate endothelial ability to release t-PA. Imidapril and candesartan induced similar systolic/diastolic BP reductions (16/12.6 and 16.1/12.2 mm Hg, respectively, P-1 per kg, P-1, P-1) than by candesartan (2.73 IU ml -1, P

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalHypertension Research
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2011

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Fibrinolysis
Insulin Resistance
Hypertension
Deamino Arginine Vasopressin
Tissue Plasminogen Activator
Blood Pressure
Glucose Clamp Technique
Brachial Artery
Plasminogen Activator Inhibitor 1
Antigens
Glucose
imidapril
candesartan
Therapeutics

Keywords

  • candesartan
  • fibrinolysis
  • imidapril
  • insulin sensitivity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension. / Fogari, Roberto; Zoppi, Annalisa; Salvadeo, Sibilla A T; Mugellini, Amedeo; Lazzari, Pierangelo; Santoro, Tara; Derosa, Giuseppe.

In: Hypertension Research, Vol. 34, No. 4, 04.2011, p. 509-515.

Research output: Contribution to journalArticle

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