Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension

Roberto Fogari; Annalisa Zoppi; Sibilla A T Salvadeo; Amedeo Mugellini; Pierangelo Lazzari; Tara Santoro; Giuseppe Derosa

doi:10.1038/hr.2010.260

Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension

Roberto Fogari, Annalisa Zoppi, Sibilla A T Salvadeo, Amedeo Mugellini, Pierangelo Lazzari, Tara Santoro, Giuseppe Derosa

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to evaluate the effects of imidapril and candesartan on fibrinolysis and insulin sensitivity in normoweight hypertensive patients. After a 2-week wash-out period, 61 patients with mild-to-moderate hypertension were randomized to imidapril or candesartan for 12 weeks. Blood pressure (BP), plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen activities were evaluated at baseline and during treatment. The patients underwent a euglycemic-hyperinsulinemic clamp (insulin sensitivity was evaluated as glucose infusion rate during the last 30 min) and a desmopressin test (with desmopressin infusion in the brachial artery) to evaluate endothelial ability to release t-PA. Imidapril and candesartan induced similar systolic/diastolic BP reductions (16/12.6 and 16.1/12.2 mm Hg, respectively, P-1 per kg, P-1, P-1) than by candesartan (2.73 IU ml ^-1, P

Original language	English
Pages (from-to)	509-515
Number of pages	7
Journal	Hypertension Research
Volume	34
Issue number	4
DOIs	https://doi.org/10.1038/hr.2010.260
Publication status	Published - Apr 2011

Keywords

candesartan
fibrinolysis
imidapril
insulin sensitivity

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension. / Fogari, Roberto; Zoppi, Annalisa; Salvadeo, Sibilla A T; Mugellini, Amedeo; Lazzari, Pierangelo; Santoro, Tara; Derosa, Giuseppe.

In: Hypertension Research, Vol. 34, No. 4, 04.2011, p. 509-515.

Research output: Contribution to journal › Article › peer-review

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AU - Lazzari, Pierangelo

AU - Santoro, Tara

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Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension

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Keywords

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