Fibrinolytic response in normal subjects to venous occlusion and DDAVP infusion

M. Cugno, L. Uziel, I. Fabrizi, B. Bottasso, F. Maggiolini, A. Agostoni

Research output: Contribution to journalArticlepeer-review

Abstract

A set of fibrinolytic parameters was measured in 40 healthy subjects before and after a venous occlusion (VO) test lasting 10 min. After VO, plasma levels of tissue-type plasminogen activator (t-PA) antigen increased in all subjects, t-PA activity increased only in 25 subjects who were considered responders and remained unchanged in 15 (non-responders). High levels of plasminogen activator inhibitor (PAI) in the non-responder group explain this discrepancy. The non-responders had basal levels of PAI activity and t-PA antigen higher than responders (p

Original languageEnglish
Pages (from-to)625-634
Number of pages10
JournalThrombosis Research
Volume56
Issue number5
DOIs
Publication statusPublished - Dec 1 1989

Keywords

  • Desmopressin
  • plasminogen activator inhibitor
  • tissue-type plasminogen activator
  • Venous occlusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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