The purpose of this study was to analyze relationship between body mass index (BMI) and mammographic/histopathologic features of fibroadenomas in postmenopausal women. The age, clinical examination, body weight and height, and mammograms of 63 postmenopausal women with fibroadenomas were reviewed retrospectively. The BMI was quantified using the Quetelet index (QI: weight/square height in kg/m2). The predominant stromal (myxoid vs, hyalin) of the mesenchymal component and the cellularity (weak vs. marked) of both the mesenchyma and the epithelial ductal components were recorded. Clinical examination found a palpable breast mass (n = 25) ranging in size from 5 to 35 mm (mean 15 mm), or was normal (n = 38). The mammograms showed opacity with ill-defined (n = 9) or well-defined borders (n = 52) and isolated clustered microcalcifications (n = 2). There were no significant relations between the mammographic patterns and the BMI. The myxoid stromal component of the mesenchyma of fibroadenomas was significantly associated with a high BMI whereas a low BMI was associated with hyalin stromal component (p = 0.0048). It was concluded that high BMI is associated with histopathologic patterns of active fibroadenomas reflecting estrogenic stimulation.
|Number of pages||5|
|Publication status||Published - Jul 1996|
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