Fibroblastic reticular cell tumor of the spleen: Report of a case and review of the entity

Maritza Martel, Dario Sarli, Maurizio Colecchia, Jorgelina Coppa, Raffaele Romito, Marcello Schiavo, Vincenzo Mazzaferro, Juan Rosai

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Fibroblastic reticulum cells (FBRCS) are stromal support cells located in the parafollicular area and deep cortex of lymph nodes and in the extrafollicular areas of the spleen and tonsils. We report a case of malignant FBRC tumor of the spleen occurring in a 61-year-old woman. Two years after splenectomy, multiple hepatic lesions were found, which were resected. Histologically, the tumor showed similar morphological features in the spleen as in the liver metastases. There was a whorled pattern of oval and spindle cells in a collagenized background admixed with an inflammatory cell infiltrate composed of lymphocytes and plasma cells. The tumor cells were positive for common muscle actin, smooth muscle actin, and focally for CD68. In situ hybridization for Epstein Barr virus was negative. To the best of our knowledge, this is the first report of malignant FBRC tumor arising in the spleen. The differential diagnosis of splenic tumors with inflammatory pseudotumor-like features is discussed.

Original languageEnglish
Pages (from-to)954-957
Number of pages4
JournalHuman Pathology
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Spleen
Neoplasms
Actins
Plasma Cell Granuloma
Reticulum
Liver
Palatine Tonsil
Splenectomy
Stromal Cells
Plasma Cells
Human Herpesvirus 4
In Situ Hybridization
Smooth Muscle
Differential Diagnosis
Lymph Nodes
Lymphocytes
Neoplasm Metastasis
Muscles

Keywords

  • Dendritic cells
  • Fibroblastic reticulum cell tumor
  • Immunohistochemistry
  • Splenic tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Fibroblastic reticular cell tumor of the spleen : Report of a case and review of the entity. / Martel, Maritza; Sarli, Dario; Colecchia, Maurizio; Coppa, Jorgelina; Romito, Raffaele; Schiavo, Marcello; Mazzaferro, Vincenzo; Rosai, Juan.

In: Human Pathology, Vol. 34, No. 9, 01.09.2003, p. 954-957.

Research output: Contribution to journalArticle

Martel, Maritza ; Sarli, Dario ; Colecchia, Maurizio ; Coppa, Jorgelina ; Romito, Raffaele ; Schiavo, Marcello ; Mazzaferro, Vincenzo ; Rosai, Juan. / Fibroblastic reticular cell tumor of the spleen : Report of a case and review of the entity. In: Human Pathology. 2003 ; Vol. 34, No. 9. pp. 954-957.
@article{516d182f993642938a5fda7b3f626a14,
title = "Fibroblastic reticular cell tumor of the spleen: Report of a case and review of the entity",
abstract = "Fibroblastic reticulum cells (FBRCS) are stromal support cells located in the parafollicular area and deep cortex of lymph nodes and in the extrafollicular areas of the spleen and tonsils. We report a case of malignant FBRC tumor of the spleen occurring in a 61-year-old woman. Two years after splenectomy, multiple hepatic lesions were found, which were resected. Histologically, the tumor showed similar morphological features in the spleen as in the liver metastases. There was a whorled pattern of oval and spindle cells in a collagenized background admixed with an inflammatory cell infiltrate composed of lymphocytes and plasma cells. The tumor cells were positive for common muscle actin, smooth muscle actin, and focally for CD68. In situ hybridization for Epstein Barr virus was negative. To the best of our knowledge, this is the first report of malignant FBRC tumor arising in the spleen. The differential diagnosis of splenic tumors with inflammatory pseudotumor-like features is discussed.",
keywords = "Dendritic cells, Fibroblastic reticulum cell tumor, Immunohistochemistry, Splenic tumor",
author = "Maritza Martel and Dario Sarli and Maurizio Colecchia and Jorgelina Coppa and Raffaele Romito and Marcello Schiavo and Vincenzo Mazzaferro and Juan Rosai",
year = "2003",
month = "9",
day = "1",
doi = "10.1016/S0046-8177(03)00399-X",
language = "English",
volume = "34",
pages = "954--957",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Fibroblastic reticular cell tumor of the spleen

T2 - Report of a case and review of the entity

AU - Martel, Maritza

AU - Sarli, Dario

AU - Colecchia, Maurizio

AU - Coppa, Jorgelina

AU - Romito, Raffaele

AU - Schiavo, Marcello

AU - Mazzaferro, Vincenzo

AU - Rosai, Juan

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Fibroblastic reticulum cells (FBRCS) are stromal support cells located in the parafollicular area and deep cortex of lymph nodes and in the extrafollicular areas of the spleen and tonsils. We report a case of malignant FBRC tumor of the spleen occurring in a 61-year-old woman. Two years after splenectomy, multiple hepatic lesions were found, which were resected. Histologically, the tumor showed similar morphological features in the spleen as in the liver metastases. There was a whorled pattern of oval and spindle cells in a collagenized background admixed with an inflammatory cell infiltrate composed of lymphocytes and plasma cells. The tumor cells were positive for common muscle actin, smooth muscle actin, and focally for CD68. In situ hybridization for Epstein Barr virus was negative. To the best of our knowledge, this is the first report of malignant FBRC tumor arising in the spleen. The differential diagnosis of splenic tumors with inflammatory pseudotumor-like features is discussed.

AB - Fibroblastic reticulum cells (FBRCS) are stromal support cells located in the parafollicular area and deep cortex of lymph nodes and in the extrafollicular areas of the spleen and tonsils. We report a case of malignant FBRC tumor of the spleen occurring in a 61-year-old woman. Two years after splenectomy, multiple hepatic lesions were found, which were resected. Histologically, the tumor showed similar morphological features in the spleen as in the liver metastases. There was a whorled pattern of oval and spindle cells in a collagenized background admixed with an inflammatory cell infiltrate composed of lymphocytes and plasma cells. The tumor cells were positive for common muscle actin, smooth muscle actin, and focally for CD68. In situ hybridization for Epstein Barr virus was negative. To the best of our knowledge, this is the first report of malignant FBRC tumor arising in the spleen. The differential diagnosis of splenic tumors with inflammatory pseudotumor-like features is discussed.

KW - Dendritic cells

KW - Fibroblastic reticulum cell tumor

KW - Immunohistochemistry

KW - Splenic tumor

UR - http://www.scopus.com/inward/record.url?scp=0141540760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141540760&partnerID=8YFLogxK

U2 - 10.1016/S0046-8177(03)00399-X

DO - 10.1016/S0046-8177(03)00399-X

M3 - Article

C2 - 14562295

AN - SCOPUS:0141540760

VL - 34

SP - 954

EP - 957

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 9

ER -