Fibroblasts from Alzheimer's disease donors do not differ from controls in response to heat shock

Beatrice Arosio, Giorgio Annoni, Carlo Vergani, Daniela C. Solano, Marco Racchi, Stefano Govoni

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated HSPs mRNA expression in cultured fibroblasts from control and AD patients. Northern blot analysis using probes for HSP70 and HSC73 revealed that HS induced a several fold increase in both mRNA. Under these condition the extent of mRNA increase was similar in controls and AD. HS elicited also a modest increase in sAPP release that was similar in control and AD. The results suggest that the ability of AD fibroblasts to produce a defensive response to HS is preserved.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Volume256
Issue number1
DOIs
Publication statusPublished - Oct 30 1998

Keywords

  • Alzheimer's disease
  • Fibroblasts
  • Heat shock response

ASJC Scopus subject areas

  • Neuroscience(all)

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