Fibroblasts in the Tumor Microenvironment

Marta Truffi, Luca Sorrentino, Fabio Corsi

Research output: Contribution to journalReview articlepeer-review

Abstract

The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.

Original languageEnglish
Pages (from-to)15-29
Number of pages15
JournalAdvances in Experimental Medicine and Biology
Volume1234
DOIs
Publication statusPublished - 2020

Keywords

  • Cancer treatment
  • Cancer-associated fibroblasts
  • Cancer-stroma crosstalk
  • Chemoresistance
  • Epithelial-to-mesenchymal transition
  • Extracellular matrix remodeling
  • Immunosuppression
  • Pro-tumorigenic cytokines
  • Targeted therapy
  • Tumor microenvironment
  • Tumor neoangiogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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