Fibronectin and cryoprecipitation

Sebastiano Garelli; Pier Luigi Meroni; Franco Montani; Fulvio Invernizzi

doi:10.1007/BF02909356

Fibronectin and cryoprecipitation

Sebastiano Garelli, Pier Luigi Meroni, Franco Montani, Fulvio Invernizzi

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Fourteen patients with essential mixed cryoglobulinemia were studied. The relevance of fibronectin (FN) in cryoprecipitation seems to be of relative importance since only two thirds of the cryoprecipitates have a higher cryocrit level when FN is present. On the other hand, the other samples show a lower precipitating activity after plasma heating at 60°C. This reduction may reflect either a structural FN modification by heating or the denaturation of other cryoprecipitating molecules. It is possible, even if not necessary, that at least in vitro FN plays a role in the cryoprecipitate formation.

Original language	English
Pages (from-to)	321-326
Number of pages	6
Journal	La Ricerca in Clinica e in Laboratorio
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/BF02909356
Publication status	Published - Apr 1986

Keywords

Cryoprecipitation
Essential mixed cryoglobulinemia
Fibrin
Fibrinogen
Fibrinogen degradation products
Fibronectin

ASJC Scopus subject areas

Clinical Biochemistry

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title = "Fibronectin and cryoprecipitation",

abstract = "Fourteen patients with essential mixed cryoglobulinemia were studied. The relevance of fibronectin (FN) in cryoprecipitation seems to be of relative importance since only two thirds of the cryoprecipitates have a higher cryocrit level when FN is present. On the other hand, the other samples show a lower precipitating activity after plasma heating at 60°C. This reduction may reflect either a structural FN modification by heating or the denaturation of other cryoprecipitating molecules. It is possible, even if not necessary, that at least in vitro FN plays a role in the cryoprecipitate formation.",

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AU - Garelli, Sebastiano

AU - Meroni, Pier Luigi

AU - Montani, Franco

AU - Invernizzi, Fulvio

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N2 - Fourteen patients with essential mixed cryoglobulinemia were studied. The relevance of fibronectin (FN) in cryoprecipitation seems to be of relative importance since only two thirds of the cryoprecipitates have a higher cryocrit level when FN is present. On the other hand, the other samples show a lower precipitating activity after plasma heating at 60°C. This reduction may reflect either a structural FN modification by heating or the denaturation of other cryoprecipitating molecules. It is possible, even if not necessary, that at least in vitro FN plays a role in the cryoprecipitate formation.

AB - Fourteen patients with essential mixed cryoglobulinemia were studied. The relevance of fibronectin (FN) in cryoprecipitation seems to be of relative importance since only two thirds of the cryoprecipitates have a higher cryocrit level when FN is present. On the other hand, the other samples show a lower precipitating activity after plasma heating at 60°C. This reduction may reflect either a structural FN modification by heating or the denaturation of other cryoprecipitating molecules. It is possible, even if not necessary, that at least in vitro FN plays a role in the cryoprecipitate formation.

KW - Cryoprecipitation

KW - Essential mixed cryoglobulinemia

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KW - Fibrinogen

KW - Fibrinogen degradation products

KW - Fibronectin

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Fibronectin and cryoprecipitation

Abstract

Keywords

ASJC Scopus subject areas

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