Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents

Waleed Ghanima, Peter Junker, Hans Carl Hasselbalch, Leonardo Boiocchi, Julia T. Geyer, Xingmin Feng, Sif Gudbrandsdottir, Attilio Orazi, James B. Bussel

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This study assessed the grade of bone marrow (BM) fibrosis and its association with a seromarker for collagen-III formation and fibrosis-related cytokines in 25 immune thrombocytopenia (ITP) patients treated with thrombopoietin receptor agonists (Tpo-RA) who had at least one BM biopsy. Assessment of 8 pre- and on-treatment BM biopsies revealed statistically significant increases in reticulin. Reticulin in biopsies performed after a median of 1·4years of treatment was graded: MF-0 in 3 (12%), MF-1 in 19 (76%), MF-2 in 2 (8%) and MF-3 in 1 (4%). No cytogenetic or flow-cytometric abnormalities were detected. Median pretreatment Procollagen III N-propeptide (PIIINP) (6·6μg/l) was significantly higher than on-treatment levels (5·6μg/l); both were higher than controls (3·4μg/l; P

Original languageEnglish
Pages (from-to)248-255
Number of pages8
JournalBritish Journal of Haematology
Volume155
Issue number2
DOIs
Publication statusPublished - Oct 2011

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Idiopathic Thrombocytopenic Purpura
Reticulin
Biopsy
Thrombopoietin Receptors
Bone Marrow
Procollagen
Primary Myelofibrosis
Cytogenetics
Fibrosis
Collagen
Therapeutics
Cytokines

Keywords

  • Hepatocyte growth factor
  • Myelofibrosis
  • Platelets
  • Procollagen
  • Transforming growth factor beta (TGF-β)

ASJC Scopus subject areas

  • Hematology

Cite this

Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents. / Ghanima, Waleed; Junker, Peter; Hasselbalch, Hans Carl; Boiocchi, Leonardo; Geyer, Julia T.; Feng, Xingmin; Gudbrandsdottir, Sif; Orazi, Attilio; Bussel, James B.

In: British Journal of Haematology, Vol. 155, No. 2, 10.2011, p. 248-255.

Research output: Contribution to journalArticle

Ghanima, W, Junker, P, Hasselbalch, HC, Boiocchi, L, Geyer, JT, Feng, X, Gudbrandsdottir, S, Orazi, A & Bussel, JB 2011, 'Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents', British Journal of Haematology, vol. 155, no. 2, pp. 248-255. https://doi.org/10.1111/j.1365-2141.2011.08845.x
Ghanima, Waleed ; Junker, Peter ; Hasselbalch, Hans Carl ; Boiocchi, Leonardo ; Geyer, Julia T. ; Feng, Xingmin ; Gudbrandsdottir, Sif ; Orazi, Attilio ; Bussel, James B. / Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents. In: British Journal of Haematology. 2011 ; Vol. 155, No. 2. pp. 248-255.
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