Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity

Ermanno Eleuteri; Antonino Di Stefano; Davide Vallese; Isabella Gnemmi; Alessandro Pitruzzella; Franco Tarro Genta; Lorena Delle Donne; Francesco Cappello; Fabio L M Ricciardolo; Pantaleo Giannuzzi

doi:10.3109/1354750X.2014.896946

Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity

Ermanno Eleuteri, Antonino Di Stefano, Davide Vallese, Isabella Gnemmi, Alessandro Pitruzzella, Franco Tarro Genta, Lorena Delle Donne, Francesco Cappello, Fabio L M Ricciardolo, Pantaleo Giannuzzi

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.

Original language	English
Pages (from-to)	214-221
Number of pages	8
Journal	Biomarkers
Volume	19
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2014.896946
Publication status	Published - 2014

Keywords

Endothelial dysfunction
Heart fibrosis
Inflammation

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis
Medicine(all)

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10.3109/1354750X.2014.896946

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Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity. / Eleuteri, Ermanno ; Di Stefano, Antonino; Vallese, Davide; Gnemmi, Isabella; Pitruzzella, Alessandro; Tarro Genta, Franco; Delle Donne, Lorena; Cappello, Francesco; Ricciardolo, Fabio L M; Giannuzzi, Pantaleo.

In: Biomarkers, Vol. 19, No. 3, 2014, p. 214-221.

Research output: Contribution to journal › Article › peer-review

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title = "Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity",

abstract = "Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.",

keywords = "Endothelial dysfunction, Heart fibrosis, Inflammation",

author = "Ermanno Eleuteri and {Di Stefano}, Antonino and Davide Vallese and Isabella Gnemmi and Alessandro Pitruzzella and {Tarro Genta}, Franco and {Delle Donne}, Lorena and Francesco Cappello and Ricciardolo, {Fabio L M} and Pantaleo Giannuzzi",

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doi = "10.3109/1354750X.2014.896946",

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AU - Eleuteri, Ermanno

AU - Di Stefano, Antonino

AU - Vallese, Davide

AU - Gnemmi, Isabella

AU - Pitruzzella, Alessandro

AU - Tarro Genta, Franco

AU - Delle Donne, Lorena

AU - Cappello, Francesco

AU - Ricciardolo, Fabio L M

AU - Giannuzzi, Pantaleo

PY - 2014

Y1 - 2014

N2 - Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.

AB - Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.

KW - Endothelial dysfunction

KW - Heart fibrosis

KW - Inflammation

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Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity

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Keywords

ASJC Scopus subject areas

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