TY - JOUR
T1 - Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity
AU - Eleuteri, Ermanno
AU - Di Stefano, Antonino
AU - Vallese, Davide
AU - Gnemmi, Isabella
AU - Pitruzzella, Alessandro
AU - Tarro Genta, Franco
AU - Delle Donne, Lorena
AU - Cappello, Francesco
AU - Ricciardolo, Fabio L M
AU - Giannuzzi, Pantaleo
PY - 2014
Y1 - 2014
N2 - Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.
AB - Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.
KW - Endothelial dysfunction
KW - Heart fibrosis
KW - Inflammation
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U2 - 10.3109/1354750X.2014.896946
DO - 10.3109/1354750X.2014.896946
M3 - Article
C2 - 24617547
AN - SCOPUS:84899756559
VL - 19
SP - 214
EP - 221
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 3
ER -