Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity

Ermanno Eleuteri, Antonino Di Stefano, Davide Vallese, Isabella Gnemmi, Alessandro Pitruzzella, Franco Tarro Genta, Lorena Delle Donne, Francesco Cappello, Fabio L M Ricciardolo, Pantaleo Giannuzzi

Research output: Contribution to journalArticlepeer-review


Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
Issue number3
Publication statusPublished - 2014


  • Endothelial dysfunction
  • Heart fibrosis
  • Inflammation

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis
  • Medicine(all)


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