TY - JOUR
T1 - Fighting multidrug resistance with a fruit extract
T2 - anti-cancer and anti-biofilm activities of Acca sellowiana
AU - Dell’Olmo, Eliana
AU - Gaglione, Rosa
AU - Pane, Katia
AU - Sorbo, Sergio
AU - Basile, Adriana
AU - Esposito, Sergio
AU - Arciello, Angela
PY - 2019/1/1
Y1 - 2019/1/1
N2 - In this study, the efficacy of Acca sellowiana fruit acetonic extract on human MDR cancer cells was tested for the first time, and it was demonstrated that the fruit extract is effective on both sensitive and resistant tumor cells. The effects of A. sellowiana extract on bacterial biofilm were also examined for the first time. By crystal violet assays and confocal microscopy analyses, it was demonstrated that the plant extract is able to strongly inhibit biofilm formation of both sensitive and resistant bacterial strains. Furthermore, antimicrobial activity assays and TEM analyses clearly demonstrated the effectiveness of plant extract on planktonic bacterial cells in both sensitive and resistant strains. Altogether, these findings intriguingly expand the panel of activities of A. sellowiana fruit extract with respect to previous reports, and open interesting perspectives to its therapeutic applications.
AB - In this study, the efficacy of Acca sellowiana fruit acetonic extract on human MDR cancer cells was tested for the first time, and it was demonstrated that the fruit extract is effective on both sensitive and resistant tumor cells. The effects of A. sellowiana extract on bacterial biofilm were also examined for the first time. By crystal violet assays and confocal microscopy analyses, it was demonstrated that the plant extract is able to strongly inhibit biofilm formation of both sensitive and resistant bacterial strains. Furthermore, antimicrobial activity assays and TEM analyses clearly demonstrated the effectiveness of plant extract on planktonic bacterial cells in both sensitive and resistant strains. Altogether, these findings intriguingly expand the panel of activities of A. sellowiana fruit extract with respect to previous reports, and open interesting perspectives to its therapeutic applications.
KW - antibiotic resistance
KW - bacterial biofilm
KW - Fruit extract
KW - multidrug resistant tumor cells
UR - http://www.scopus.com/inward/record.url?scp=85067544358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067544358&partnerID=8YFLogxK
U2 - 10.1080/14786419.2019.1624961
DO - 10.1080/14786419.2019.1624961
M3 - Article
C2 - 31172798
AN - SCOPUS:85067544358
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
ER -