Fighting multidrug resistance with a fruit extract: anti-cancer and anti-biofilm activities of Acca sellowiana

Eliana Dell’Olmo, Rosa Gaglione, Katia Pane, Sergio Sorbo, Adriana Basile, Sergio Esposito, Angela Arciello

Research output: Contribution to journalArticle

Abstract

In this study, the efficacy of Acca sellowiana fruit acetonic extract on human MDR cancer cells was tested for the first time, and it was demonstrated that the fruit extract is effective on both sensitive and resistant tumor cells. The effects of A. sellowiana extract on bacterial biofilm were also examined for the first time. By crystal violet assays and confocal microscopy analyses, it was demonstrated that the plant extract is able to strongly inhibit biofilm formation of both sensitive and resistant bacterial strains. Furthermore, antimicrobial activity assays and TEM analyses clearly demonstrated the effectiveness of plant extract on planktonic bacterial cells in both sensitive and resistant strains. Altogether, these findings intriguingly expand the panel of activities of A. sellowiana fruit extract with respect to previous reports, and open interesting perspectives to its therapeutic applications.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - Jan 1 2019

Keywords

  • antibiotic resistance
  • bacterial biofilm
  • Fruit extract
  • multidrug resistant tumor cells

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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