Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells

Elena Muraro, Anna Merlo, Debora Martorelli, Michela Cangemi, Silvia Dalla Santa, Riccardo Dolcetti, Antonio Rosato

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and specific functions. Nonetheless, a growing body of evidence indicates that CD4+ T cells can also exert a direct effector activity, which depends on intrinsic cytotoxic properties acquired and carried out along with the evolution of several pathogenic infections. The relevant role of CD4+ T cell lytic features in the control of such infectious conditions also leads to their exploitation as a new immunotherapeutic approach. This review aims at summarizing currently available data about functional and therapeutic relevance of cytotoxic CD4+ T cells in the context of viral infections and virus-driven tumors.

Original languageEnglish
Article number197
Number of pages20
JournalFrontiers in Immunology
Volume8
Issue numberFEB
DOIs
Publication statusPublished - Feb 27 2017

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Oncogenic Viruses
Virus Diseases
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Transcription Factors
Cytokines
Infection
Population
Therapeutics

Keywords

  • CD4 T cells
  • Cytotoxicity
  • Immunotherapy
  • Viral infection
  • Virus-driven tumors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells. / Muraro, Elena; Merlo, Anna; Martorelli, Debora; Cangemi, Michela; Santa, Silvia Dalla; Dolcetti, Riccardo; Rosato, Antonio.

In: Frontiers in Immunology, Vol. 8, No. FEB, 197, 27.02.2017.

Research output: Contribution to journalReview article

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