Filamin A (FLNA) Plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells

E. Peverelli; E. Giardino; D. Treppiedi; E. Vitali; V. Cambiaghi; M. Locatelli; G. B. Lasio; A. Spada; A. G. Lania; G. Mantovani

doi:10.1210/en.2014-1063

Filamin A (FLNA) Plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells

E. Peverelli, E. Giardino, D. Treppiedi, E. Vitali, V. Cambiaghi, M. Locatelli, G. B. Lasio, A. Spada, A. G. Lania, G. Mantovani

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Abstract

Somatostatin receptor type 2 (SST2) is the main pharmacological target of medical therapy for GH-secreting pituitary tumors, but molecular mechanisms regulating its expression and signaling are largely unknown. The aim of this study was to investigate the role of cytoskeleton protein filamin A (FLNA) in SST2 expression and signaling in somatotroph tumor cells. We found a highly variable expression of FLNA in human GH-secreting tumors, without a correlation with SST2 levels. FLNA silencing in human tumoral cells did not affect SST2 expression and localization but abolished the SST2-induced reduction of cyclin D1 (-37% ± 15% incontrol cells, P

Original language	English
Pages (from-to)	2932-2941
Number of pages	10
Journal	Endocrinology
Volume	155
Issue number	8
DOIs	https://doi.org/10.1210/en.2014-1063
Publication status	Published - 2014

ASJC Scopus subject areas

Endocrinology

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Peverelli, E., Giardino, E., Treppiedi, D., Vitali, E., Cambiaghi, V., Locatelli, M., Lasio, G. B., Spada, A., Lania, A. G., & Mantovani, G. (2014). Filamin A (FLNA) Plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells. Endocrinology, 155(8), 2932-2941. https://doi.org/10.1210/en.2014-1063

Peverelli, E, Giardino, E, Treppiedi, D, Vitali, E, Cambiaghi, V, Locatelli, M, Lasio, GB, Spada, A, Lania, AG & Mantovani, G 2014, 'Filamin A (FLNA) Plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells', Endocrinology, vol. 155, no. 8, pp. 2932-2941. https://doi.org/10.1210/en.2014-1063

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abstract = "Somatostatin receptor type 2 (SST2) is the main pharmacological target of medical therapy for GH-secreting pituitary tumors, but molecular mechanisms regulating its expression and signaling are largely unknown. The aim of this study was to investigate the role of cytoskeleton protein filamin A (FLNA) in SST2 expression and signaling in somatotroph tumor cells. We found a highly variable expression of FLNA in human GH-secreting tumors, without a correlation with SST2 levels. FLNA silencing in human tumoral cells did not affect SST2 expression and localization but abolished the SST2-induced reduction of cyclin D1 (-37% ± 15% incontrol cells, P",

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AU - Peverelli, E.

AU - Giardino, E.

AU - Treppiedi, D.

AU - Vitali, E.

AU - Cambiaghi, V.

AU - Locatelli, M.

AU - Lasio, G. B.

AU - Spada, A.

AU - Lania, A. G.

AU - Mantovani, G.

PY - 2014

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AB - Somatostatin receptor type 2 (SST2) is the main pharmacological target of medical therapy for GH-secreting pituitary tumors, but molecular mechanisms regulating its expression and signaling are largely unknown. The aim of this study was to investigate the role of cytoskeleton protein filamin A (FLNA) in SST2 expression and signaling in somatotroph tumor cells. We found a highly variable expression of FLNA in human GH-secreting tumors, without a correlation with SST2 levels. FLNA silencing in human tumoral cells did not affect SST2 expression and localization but abolished the SST2-induced reduction of cyclin D1 (-37% ± 15% incontrol cells, P

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Filamin A (FLNA) Plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells

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