Filamin A (FLNA) Plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells

E. Peverelli, E. Giardino, D. Treppiedi, E. Vitali, V. Cambiaghi, M. Locatelli, G. B. Lasio, A. Spada, A. G. Lania, G. Mantovani

Research output: Contribution to journalArticle

Abstract

Somatostatin receptor type 2 (SST2) is the main pharmacological target of medical therapy for GH-secreting pituitary tumors, but molecular mechanisms regulating its expression and signaling are largely unknown. The aim of this study was to investigate the role of cytoskeleton protein filamin A (FLNA) in SST2 expression and signaling in somatotroph tumor cells. We found a highly variable expression of FLNA in human GH-secreting tumors, without a correlation with SST2 levels. FLNA silencing in human tumoral cells did not affect SST2 expression and localization but abolished the SST2-induced reduction of cyclin D1 (-37% ± 15% incontrol cells, P

Original languageEnglish
Pages (from-to)2932-2941
Number of pages10
JournalEndocrinology
Volume155
Issue number8
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Endocrinology

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