fimA-folD genes linkage in Salmonella identifies a putative junctional site of chromosomal rearrangement in the enterobacterial genome

Gian Maria Rossolini, Patrizia Muscas, Alessandra Chiesurin, Giuseppe Satta

Research output: Contribution to journalArticle

Abstract

Analysis of the Salmonella chromosomal region located upstream of the fimA gene (coding for the major type 1 fimbrial subunit) showed a close linkage of this gene to the folD gene (coding for the enzyme 5,10-methylenetetrahydrofolate dehydrogenase/5, 10-methenyltetrahydrofolate cyclohydrolase), indicating that the fim gene cluster of Salmonella, unlike that of Escherichia coli, has no regulatory genes located upstream of fimA and apparently terminates with this gene. The respective locations of the fim and folD genes in the E. coli and Salmonella genetic maps suggests that the fimA-folD intergenic region of Salmonella encompasses a junctional site of a genetic rearrangement that probably originated from the different chromosomal location of the fim genes in these species.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalFEMS Microbiology Letters
Volume119
Issue number3
Publication statusPublished - Jun 15 1994

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Keywords

  • fim Genes
  • folD Gene
  • Genetic rearrangement
  • Salmonella

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

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