Final height outcome of growth hormone-deficient patients treated since less than five years of age

F. De Luca, M. Maghnie, T. Arrigo, F. Lombardo, M. F. Messina, S. Bernasconi

Research output: Contribution to journalArticlepeer-review

Abstract

Thirteen growth hormone deficient infants underwent substitutive treatment for at least 9 years, since less than 5 years of age until adulthood. They presented with average growth failure reaching 4.1 SDS and attained an adult mean height close to target height. In eight subjects final height exceeded the respective target height and only three patients failed to achieve an end height within the target range. The analysis of the factors conditioning ultimate stature pointed out that height outcome correlated negatively with chronological age at therapy initiation and positively with height at puberty onset. It is concluded that full catch-up growth to target percentile is possible in growth hormone-deficient children, provided that substitutive treatment is begun within the first 5 years of life. This conclusion is substantiated for the first time by data on end stature.

Original languageEnglish
Pages (from-to)1167-1171
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume85
Issue number10
Publication statusPublished - 1996

Keywords

  • Early growth hormone treatment
  • Final height outcome
  • Full catch-up growth
  • Growth hormone deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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