The final report describes data concerning 23,262 renal biopsies (RB) collected over a 9-year period (19871995) by the Italian Registry of Renal Biopsies (IRRB). In the first two years (1987-1988), only the histological diagnosis have been recorded, while in the subsequent years additional data as sex, age and clinical symptoms were obtained. In the last three years (1993-1995), data from 96% of Renal Units routinely performing RB were collected and then the likely annual incidences per million of population (pmp) were estimated. The results showed that 92.4% of RB were performed in adults, while 7.6 in children (age ≤ 14 years), 59.9% in males and 40.1% in females, 86.3% in native kidneys and 10.1% in renal allografts, while in 3.6% inadequate renal specimen was obtained. RB were evaluated by light microscopy (98%), immunofluorescence (87.5%) and electron microscopy (35.5%). A further analysis on 20074 RB performed on native kidneys showed the following nephropaties subdivided in five groups: primary glomerulonephritis (GN) in 60% of cases, secondary GN in 25.4%, tubulo-interstitial nephritis in 3.8%, vascular diseases associated nephropaties in 3.4% and others (miscellaneous) in 7.4%. The annual incidences showed little differences in respect to these values. Among 12,040 primary GN, the most frequent were IgAN (35.9%), membranous GN (20.4%) and focal and segmental glomerulosclerosis (11.4%). Among 5092 secondary GN, the most frequent subgroups were renal diseases due to immunopathies (51.2%) and dysgammaglobulinemia (26.2%). In the former subgroup (2609 RB), lupus nephritis (50.7%) and necrotizing vasculitis (26.0%) were the most frequent, while amiloidosis (41.0%), cryoglobulinemic GN (31.2%) and multiple myeloma (16.2%) were the most frequent forms of dysgammaglobulinemia (1336 RB). The percent distribution of 18,405 clinical syndromes relative to 16530 RB showed that the most common indications to perform RB were urinary abnormalities (30.9%) and nephrotic syndrome (27.3%), while recurrent macrohematuria (8.6%) and nephritic syndrome (5.4%) were less frequent. Acute and chronic renal failure were present in 8.8% and 19.0% of cases, respectively. Membranous GN (32.1%) represented the most frequent diagnosis in patient with nephrotic syndrome, while post-streptococcal GN (15.9%) and IgAN (15.6%) in patients with nephritic syndrome. IgAN was the most frequent diagnosis in patient with urinary abnormalities and recurrent macrohematuria (30.6% and 71.6%, respectively). Epidemiological data obtained in last three years (1993-1995) demonstrated that among primary GN the most incident forms were IgAN (11.1/pmp in the year 1995) and membranous GN (5.6/pmp), while lupus nephritis was more frequent in secondary GN (2.8/pmp). In conclusion, the IRRB is a resource of data for nephrologists on frequency of nephropaties and clinical syndromes; the presence of IRRB in an Internet site allows a better diffusion of these informations throughout the scientific community and the organization of clinical and epidemiological studies. For this purpose a new case report form has been introduced in 1996, which contains more records for each patient receiving RB.
|Number of pages||10|
|Journal||Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia|
|Publication status||Published - 1998|
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