Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma

M. E. Gore, C. Szczylik, C. Porta, S. Bracarda, G. A. Bjarnason, S. Oudard, S. H. Lee, J. Haanen, D. Castellano, E. Vrdoljak, P. Schöffski, P. Mainwaring, R. E. Hawkins, L. Crinò, T. M. Kim, G. Carteni, W. E E Eberhardt, K. Zhang, K. Fly, E. MatczakM. J. Lechuga, S. Hariharan, R. Bukowski

Research output: Contribution to journalArticle

Abstract

Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alleles with disease-specific outcomes.Methods:We genotyped 1354 individuals treated for localised PCa between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to phenotypic data. We investigated associations between 61 SNPs and disease-specific end points using multivariable analysis and also determined if SNPs were associated with PSA at diagnosis.Results:Seven SNPs showed associations on multivariable analysis (P

Original languageEnglish
Pages (from-to)12-19
Number of pages8
JournalBritish Journal of Cancer
Volume113
Issue number1
DOIs
Publication statusPublished - Jun 30 2015

Keywords

  • expanded-access trial
  • prognosis
  • Renal cell carcinoma
  • sunitinib
  • tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Gore, M. E., Szczylik, C., Porta, C., Bracarda, S., Bjarnason, G. A., Oudard, S., Lee, S. H., Haanen, J., Castellano, D., Vrdoljak, E., Schöffski, P., Mainwaring, P., Hawkins, R. E., Crinò, L., Kim, T. M., Carteni, G., Eberhardt, W. E. E., Zhang, K., Fly, K., ... Bukowski, R. (2015). Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma. British Journal of Cancer, 113(1), 12-19. https://doi.org/10.1038/bjc.2015.199