Final shape of biovascular scaffolds and clinical outcome. Results from a multicenter all-comers study with intravascular imaging

Bernardo Cortese, Davide Piraino, Roberto A. Latini, Dennis Zavalloni, Alfonso Ielasi, Piefrancesco Agostoni, Pietro Mazzarotto, Maurizio Tespili, Romano Seregni

Research output: Contribution to journalArticle

Abstract

Aims Radial strength of bioresorbable vascular scaffolds (BVS) implanted in coronary arteries is still under debate. Moreover, their final shape patterns, when implanted in an all-comer, unselected population, have not yet been completely correlated with clinical outcome and should be better investigated. Methods and results A multicenter collaborative analysis was performed on all consecutive patients with native coronary artery disease undergoing PCI with intravascular imaging-guided BVS implantation. The BVS was arbitrarily categorized as having a final “oval shape” through intravascular imaging, if maximal lumen diameter was longer than 150% of minimal lumen diameter at the target lesion. Primary study-endpoint was device-oriented major adverse events (DOCE) at mid-term follow-up. Sixty-seven consecutive patients were evaluated at 6 European centers. Mean patient age was 58 ± 11 years, and 12 patients (18%) had diabetes. Mean percent diameter stenosis was 79 ± 12.5%. Average lesion length was 24.4 ± 13.8 mm and 66% of lesions were AHA/ACC type B2/C. Postdilation rate was 91% and all BVS resulted well apposed to the vessel wall. Procedural success was achieved in all patients and 10 (14.9%) had an “oval shape” at intravascular imaging. This occurrence was not associated with an increase in periprocedural myocardial infarction (p = 0.37) or DOCE during hospitalization (p = 0.65). Seven-month DOCE occurred in 3 patients (5.6%) of the oval shape group, they were target-vessel revascularization and did not differ significantly between patients with vs. without final “oval shape” (p = 0.34). We did not register episodes of scaffold thromboses. Conclusions In an all-comer population with complex coronary lesions treated with BVS, a final oval shape after postdilation was not rare and not associated with immediate and medium term adverse events.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalInternational Journal of Cardiology
Volume228
DOIs
Publication statusPublished - Feb 1 2017

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Blood Vessels
Population
Coronary Artery Disease
Coronary Vessels
Pathologic Constriction
Hospitalization
Thrombosis
Myocardial Infarction
Equipment and Supplies

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

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Final shape of biovascular scaffolds and clinical outcome. Results from a multicenter all-comers study with intravascular imaging. / Cortese, Bernardo; Piraino, Davide; Latini, Roberto A.; Zavalloni, Dennis; Ielasi, Alfonso; Agostoni, Piefrancesco; Mazzarotto, Pietro; Tespili, Maurizio; Seregni, Romano.

In: International Journal of Cardiology, Vol. 228, 01.02.2017, p. 209-213.

Research output: Contribution to journalArticle

Cortese, Bernardo ; Piraino, Davide ; Latini, Roberto A. ; Zavalloni, Dennis ; Ielasi, Alfonso ; Agostoni, Piefrancesco ; Mazzarotto, Pietro ; Tespili, Maurizio ; Seregni, Romano. / Final shape of biovascular scaffolds and clinical outcome. Results from a multicenter all-comers study with intravascular imaging. In: International Journal of Cardiology. 2017 ; Vol. 228. pp. 209-213.
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T1 - Final shape of biovascular scaffolds and clinical outcome. Results from a multicenter all-comers study with intravascular imaging

AU - Cortese, Bernardo

AU - Piraino, Davide

AU - Latini, Roberto A.

AU - Zavalloni, Dennis

AU - Ielasi, Alfonso

AU - Agostoni, Piefrancesco

AU - Mazzarotto, Pietro

AU - Tespili, Maurizio

AU - Seregni, Romano

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AB - Aims Radial strength of bioresorbable vascular scaffolds (BVS) implanted in coronary arteries is still under debate. Moreover, their final shape patterns, when implanted in an all-comer, unselected population, have not yet been completely correlated with clinical outcome and should be better investigated. Methods and results A multicenter collaborative analysis was performed on all consecutive patients with native coronary artery disease undergoing PCI with intravascular imaging-guided BVS implantation. The BVS was arbitrarily categorized as having a final “oval shape” through intravascular imaging, if maximal lumen diameter was longer than 150% of minimal lumen diameter at the target lesion. Primary study-endpoint was device-oriented major adverse events (DOCE) at mid-term follow-up. Sixty-seven consecutive patients were evaluated at 6 European centers. Mean patient age was 58 ± 11 years, and 12 patients (18%) had diabetes. Mean percent diameter stenosis was 79 ± 12.5%. Average lesion length was 24.4 ± 13.8 mm and 66% of lesions were AHA/ACC type B2/C. Postdilation rate was 91% and all BVS resulted well apposed to the vessel wall. Procedural success was achieved in all patients and 10 (14.9%) had an “oval shape” at intravascular imaging. This occurrence was not associated with an increase in periprocedural myocardial infarction (p = 0.37) or DOCE during hospitalization (p = 0.65). Seven-month DOCE occurred in 3 patients (5.6%) of the oval shape group, they were target-vessel revascularization and did not differ significantly between patients with vs. without final “oval shape” (p = 0.34). We did not register episodes of scaffold thromboses. Conclusions In an all-comer population with complex coronary lesions treated with BVS, a final oval shape after postdilation was not rare and not associated with immediate and medium term adverse events.

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