Abstract
This monograph summarizes one of the sessions of the XI Workshop on Neurobiology of Epilepsy (WONOEP), and provides a critical review of the current state of the field. Speakers and discussants focused on several broad topics: (1) the coexistence of inflammatory processes encompassing several distinct signal-transduction pathways with the epileptogenic process; (2) evidence for the contribution of specific inflammatory molecules and processes to the onset and progression of epilepsy, as well as to epilepsy-related morbidities including depression; (3) the complexity and intricate cross-talk of the pathways involved in inflammation, and the discrete, often opposite roles of a given mediator in neurons versus other cell types. These complexities highlight the challenges confronting the field as it aims to define inflammatory molecules as promising targets for epilepsy prevention and treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1113-1118 |
| Number of pages | 6 |
| Journal | Epilepsia |
| Volume | 53 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2012 |
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Keywords
- Brain inflammation
- Disease-modifying
- Epilepsy
- Epileptogenesis
- Therapy
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Finding a better drug for epilepsy : Antiinflammatory targets. / Dedeurwaerdere, Stefanie; Friedman, Alon; Fabene, Paolo F.; Mazarati, Andrèy; Murashima, Yoshiya L.; Vezzani, Annamaria; Baram, Tallie Z.
In: Epilepsia, Vol. 53, No. 7, 07.2012, p. 1113-1118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Finding a better drug for epilepsy
T2 - Antiinflammatory targets
AU - Dedeurwaerdere, Stefanie
AU - Friedman, Alon
AU - Fabene, Paolo F.
AU - Mazarati, Andrèy
AU - Murashima, Yoshiya L.
AU - Vezzani, Annamaria
AU - Baram, Tallie Z.
PY - 2012/7
Y1 - 2012/7
N2 - This monograph summarizes one of the sessions of the XI Workshop on Neurobiology of Epilepsy (WONOEP), and provides a critical review of the current state of the field. Speakers and discussants focused on several broad topics: (1) the coexistence of inflammatory processes encompassing several distinct signal-transduction pathways with the epileptogenic process; (2) evidence for the contribution of specific inflammatory molecules and processes to the onset and progression of epilepsy, as well as to epilepsy-related morbidities including depression; (3) the complexity and intricate cross-talk of the pathways involved in inflammation, and the discrete, often opposite roles of a given mediator in neurons versus other cell types. These complexities highlight the challenges confronting the field as it aims to define inflammatory molecules as promising targets for epilepsy prevention and treatment.
AB - This monograph summarizes one of the sessions of the XI Workshop on Neurobiology of Epilepsy (WONOEP), and provides a critical review of the current state of the field. Speakers and discussants focused on several broad topics: (1) the coexistence of inflammatory processes encompassing several distinct signal-transduction pathways with the epileptogenic process; (2) evidence for the contribution of specific inflammatory molecules and processes to the onset and progression of epilepsy, as well as to epilepsy-related morbidities including depression; (3) the complexity and intricate cross-talk of the pathways involved in inflammation, and the discrete, often opposite roles of a given mediator in neurons versus other cell types. These complexities highlight the challenges confronting the field as it aims to define inflammatory molecules as promising targets for epilepsy prevention and treatment.
KW - Brain inflammation
KW - Disease-modifying
KW - Epilepsy
KW - Epileptogenesis
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=84863717234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863717234&partnerID=8YFLogxK
U2 - 10.1111/j.1528-1167.2012.03520.x
DO - 10.1111/j.1528-1167.2012.03520.x
M3 - Article
C2 - 22691043
AN - SCOPUS:84863717234
VL - 53
SP - 1113
EP - 1118
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 7
ER -