Fine mapping of five human skeletal muscle genes: Alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast

Natascia Tiso, Luca Rampoldi, Alberto Pallavicini, Rosanna Zimbello, Davide Pandolfo, Giorgio Valle, Gerolamo Lanfranchi, Gian Antonio Danieli

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper the chromosomal localization of the human skeletal muscle genes Troponin-I slow-twitch (TNNI1), Troponin-I fast-twitch (TNNI2), and Troponin-C fast (TNNC2) and the refinement of the position alpha-Tropomyosin (TPM1) and beta-Tropomyosin (TPM2) are reported. By radiation hybrid mapping, TPM1 was assigned to chromosome 15q22.1, TPM2 to chromosome 9p13.2-p13.1, TNNI1 to chromosome 1q31.3, TNNI2 to chromosome 11p15.5, and TNNC2 to chromosome 20q12-q13.11. The genomic distribution of these genes is discussed, with particular emphasis on the cluster organization of the Troponin genes.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume230
Issue number2
DOIs
Publication statusPublished - Jan 13 1997

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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