Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

Hailiang Huang, Priya Duggal, Chloe L. Thio, Rachel Latanich, James J. Goedert, Alessandra Mangia, Andrea L. Cox, Gregory D. Kirk, Shruti Mehta, Jasneet Aneja, Laurent Alric, Sharyne M. Donfield, Matthew E. Cramp, Salim I. Khakoo, Leslie H. Tobler, Michael Busch, Graeme J. Alexander, Hugo R. Rosen, Brian R. Edlin, Florencia P. SegalGeorg M. Lauer, David L. Thomas, Mark J. Daly, Raymond T. Chung, Arthur Y. Kim

Research output: Contribution to journalArticle

Abstract

Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.

Original languageEnglish
Article number15843
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

Huang, H., Duggal, P., Thio, C. L., Latanich, R., Goedert, J. J., Mangia, A., Cox, A. L., Kirk, G. D., Mehta, S., Aneja, J., Alric, L., Donfield, S. M., Cramp, M. E., Khakoo, S. I., Tobler, L. H., Busch, M., Alexander, G. J., Rosen, H. R., Edlin, B. R., ... Kim, A. Y. (2017). Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection. Scientific Reports, 7(1), [15843]. https://doi.org/10.1038/s41598-017-16011-2