Fine needle aspiration biopsy diagnosis of giant-cell tumor of bone. An experience with nine cases

A. Vetrani, F. Fulciniti, R. Boschi, G. Marino, P. Zeppa, G. Troncone, L. Palombini

Research output: Contribution to journalArticlepeer-review

Abstract

The cytologic findings in nine cases of giant-cell tumor (osteoclastoma) of bone diagnosed by fine needle aspiration (FNA) biopsy are described. The aspirates contained a dual population of cells, consisting of mononucleated tumor cells and multinucleated giant cells (osteoclasts). The tumor cells were usually evident in the FNA smears as cohesive perivascular clusters; some were present as sheets or single cells. The most striking feature, which may best suggest the diagnosis of giant-cell tumor in an FNA smear, was the attachment of the osteoclasts to the cohesive groups of tumor cells. Even when the cells were more dissociated, there was a rather regular distribution of the two types of cells. This series further demonstrates that FNA biopsy permits an accurate cytopathologic diagnosis of giant-cell tumor and that its use can clarify the clinical and radiologic impressions of these bony lesions preoperatively. The differential diagnosis between osteoclastoma and other giant-cell-containing bone lesions is discussed in detail.

Original languageEnglish
Pages (from-to)863-867
Number of pages5
JournalActa Cytologica
Volume34
Issue number6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

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