Fine-needle aspiration cytology and 99mTc-pertechnetate scintigraphy together in patients with differentiated thyroid carcinoma

Franco Lumachi, Micaela Fabbro, Alberto Tregnaghi, Lidija Antunovic, Franco Bui, Diego Cecchin, Pietro Zucchetta, Ambrogio Fassina

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The aim of this study was to evaluate the usefulness of fine-needle aspiration cytology (FNAC) and 99mTc-pertechnetate scintigraphy (TS) together in patients with differentiated thyroid carcinoma. Data from a series of 357 patients (284 women and 73 men, median age 43 years, range 19-73) with solitary thyroid nodule and no signs of hyperfunction, who had undergone both FNAC and TS prior to surgery, were retrospectively reviewed. FNAC distinguished 3 groups of TN (benign, follicular neoplasm, cancer), while patients with 'cold' TN were considered at risk of having a thyroid tumor. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were: 95%, 21%, 20%, 95% and 34% for TS; 82%, 99%, 96%, 96% and 96% for FNAC; 98%, 99%, 97%, 98%, and 99% for TS and FNAC together, respectively. In conclusion, patients with 'cold' TN and FNAC suggesting follicular neoplasm should be considered at risk of having cancer.

Original languageEnglish
Pages (from-to)3083-3086
Number of pages4
JournalAnticancer Research
Volume30
Issue number7
Publication statusPublished - Jul 2010

Fingerprint

Sodium Pertechnetate Tc 99m
Fine Needle Biopsy
Thyroid Neoplasms
Radionuclide Imaging
Cell Biology
Neoplasms
Thyroid Nodule
Thyroid Gland
Sensitivity and Specificity

Keywords

  • Tc-pertechnetate
  • Fine-needle aspiration cytology
  • FNAB
  • FNAC
  • Thyroid cancer
  • Thyroid gland
  • Thyroid nodule
  • Thyroid scintigraphy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lumachi, F., Fabbro, M., Tregnaghi, A., Antunovic, L., Bui, F., Cecchin, D., ... Fassina, A. (2010). Fine-needle aspiration cytology and 99mTc-pertechnetate scintigraphy together in patients with differentiated thyroid carcinoma. Anticancer Research, 30(7), 3083-3086.

Fine-needle aspiration cytology and 99mTc-pertechnetate scintigraphy together in patients with differentiated thyroid carcinoma. / Lumachi, Franco; Fabbro, Micaela; Tregnaghi, Alberto; Antunovic, Lidija; Bui, Franco; Cecchin, Diego; Zucchetta, Pietro; Fassina, Ambrogio.

In: Anticancer Research, Vol. 30, No. 7, 07.2010, p. 3083-3086.

Research output: Contribution to journalArticle

Lumachi, F, Fabbro, M, Tregnaghi, A, Antunovic, L, Bui, F, Cecchin, D, Zucchetta, P & Fassina, A 2010, 'Fine-needle aspiration cytology and 99mTc-pertechnetate scintigraphy together in patients with differentiated thyroid carcinoma', Anticancer Research, vol. 30, no. 7, pp. 3083-3086.
Lumachi, Franco ; Fabbro, Micaela ; Tregnaghi, Alberto ; Antunovic, Lidija ; Bui, Franco ; Cecchin, Diego ; Zucchetta, Pietro ; Fassina, Ambrogio. / Fine-needle aspiration cytology and 99mTc-pertechnetate scintigraphy together in patients with differentiated thyroid carcinoma. In: Anticancer Research. 2010 ; Vol. 30, No. 7. pp. 3083-3086.
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