Fine-needle aspiration cytology of angiolymphoid hyperplasia with eosinophilia: a case report with electron microscopy and immunohistochemistry.

G. Pettinato, L. Insabato, A. De Chiara, V. Ruocco, L. Bucci

Research output: Contribution to journalArticle

Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon vascular inflammatory lesion usually involving the dermis or subcutaneous tissue of the head-neck region of middle-aged women. Histologically, this lesion shows a florid proliferation of vessels lined by particular endothelial cells and an inflammatory infiltrate composed of lymphocytes and eosinophils. The fine-needle aspiration (FNA) cytology of a nodular lesion in the retroauricolar region of a 18-yr-old woman showed spindle-shaped and polygonal cells with vesicular nuclei and deeply eosinophilic cytoplasm containing well-defined vacuoles in a background of eosinophils and lymphocytes. These features were consistent with a proliferation of epithelioid endothelial cells, and a diagnosis of ALHE was suggested. The histology confirmed the preoperatory diagnosis, and ultrastructural and immunohistochemical studies further demonstrated the endothelial nature of epithelial-appearing cells. Because the clinical appearance of the lesion may mimic a large number of benign and malignant diseases, a preoperatory diagnosis of ALHE is rarely made. The FNA cytology may represent a simple and reliable method with which to study and diagnose proliferations of epithelioid endothelial cells.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalDiagnostic Cytopathology
Volume5
Issue number1
Publication statusPublished - 1989

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Angiolymphoid Hyperplasia with Eosinophilia
Fine Needle Biopsy
Cell Biology
Electron Microscopy
Immunohistochemistry
Epithelioid Cells
Endothelial Cells
Eosinophils
Lymphocytes
Subcutaneous Tissue
Dermis
Vacuoles
Blood Vessels
Histology
Cytoplasm
Neck
Epithelial Cells
Head

ASJC Scopus subject areas

  • Anatomy

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Fine-needle aspiration cytology of angiolymphoid hyperplasia with eosinophilia : a case report with electron microscopy and immunohistochemistry. / Pettinato, G.; Insabato, L.; De Chiara, A.; Ruocco, V.; Bucci, L.

In: Diagnostic Cytopathology, Vol. 5, No. 1, 1989, p. 88-94.

Research output: Contribution to journalArticle

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