TY - JOUR
T1 - Fine needle aspiration of metastatic epithelioid angiosarcoma
T2 - A report of 2 cases
AU - Fulciniti, Franco
AU - Di Mattia, Diana
AU - Bove, Patrizia
AU - Mastro, Angelo Antonio
AU - De Chiara, Annarosaria
AU - Botti, Gerardo
AU - Petrillo, Antonella
AU - Apice, Gaetano
PY - 2008
Y1 - 2008
N2 - Background: Epithelioid angiosarcomas (EAs) are uncommon mesenchymal tumors occurring in the thyroid, deep-seated soft tissues, parenchymal organs and, more rarely, superficial soft tissues of the head and neck. Due to their cytologic and immunocytochemical presentation on fine needle aspiration cytology (FNAC) samples, these neoplasms may closely mimic a number of different tumors, potentially causing an erroneous cytopathologic diagnosis unless immunophenotypical markers of vascular differentiation are sought in the cellular material. Cases: A 68-year-old man with a 1-year history of total thyroidectomy for EA presented with a suspicious right neck node and underwent FNA. A 63-year-old woman with a history of recurring multiple scalp nodules diagnosed as EA ultimately developed small multiple, bilateral lymph nodes in the neck and underwent FNA. In both cases a cytopathologic diagnosis of metastatic EA was made. Conclusion: The cytopathologic diagnosis of EA is a challenge. Knowledge of the clinical history is of great help in diagnosing metastatic lesions. The cytopathologic picture of metastases is a useful way for cytopathologists to gain confidence with presentation of this rare entity in primary sites on FNAC samples. Cytopathologic hints of vascular differentiation should be sought in the cytopathologic material when a diagnosis of EA is entertained.
AB - Background: Epithelioid angiosarcomas (EAs) are uncommon mesenchymal tumors occurring in the thyroid, deep-seated soft tissues, parenchymal organs and, more rarely, superficial soft tissues of the head and neck. Due to their cytologic and immunocytochemical presentation on fine needle aspiration cytology (FNAC) samples, these neoplasms may closely mimic a number of different tumors, potentially causing an erroneous cytopathologic diagnosis unless immunophenotypical markers of vascular differentiation are sought in the cellular material. Cases: A 68-year-old man with a 1-year history of total thyroidectomy for EA presented with a suspicious right neck node and underwent FNA. A 63-year-old woman with a history of recurring multiple scalp nodules diagnosed as EA ultimately developed small multiple, bilateral lymph nodes in the neck and underwent FNA. In both cases a cytopathologic diagnosis of metastatic EA was made. Conclusion: The cytopathologic diagnosis of EA is a challenge. Knowledge of the clinical history is of great help in diagnosing metastatic lesions. The cytopathologic picture of metastases is a useful way for cytopathologists to gain confidence with presentation of this rare entity in primary sites on FNAC samples. Cytopathologic hints of vascular differentiation should be sought in the cytopathologic material when a diagnosis of EA is entertained.
KW - Angiosarcoma, epithelioid
KW - Aspiration cytology, fine-needle
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M3 - Article
C2 - 18833827
AN - SCOPUS:52249101969
VL - 52
SP - 612
EP - 618
JO - Acta Cytologica
JF - Acta Cytologica
SN - 0001-5547
IS - 5
ER -