Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies

Sabrina Matà, Maria Grazia Giudizi, Maria Totaro, Antonello Grippo, Sandra Fedi, Sandro Sorbi

Research output: Contribution to journalArticle

Abstract

Phospholipids are abundantly represented within the nervous system. Aim of our study was to evaluate the presence and fine specificity of anti phospholipid antibodies (aPLAb) among patients with monoclonal gammopathy associated neuropathy. Thirty nine percent of these patients had high titers of aPLAb, mostly associated with low levels of anti beta2 glycoprotein I, which suggests different antibody specificity compared to patients with anti phospholipid syndrome. Further 6/48 patients with dysimmune neuropathy without monoclonal gammopathy had positive aPLAb titers. APLAb strongly cross-reacted with sulfatide. These findings suggest an adjuntive role of aPLAb on nerve damage and may help to better understand the nerve binding properties of anti-sulfatide antibodies.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJournal of Neuroimmunology
Volume182
Issue number1-2
DOIs
Publication statusPublished - Jan 2007

Fingerprint

beta 2-Glycoprotein I
Paraproteinemias
Antibody Specificity
Anti-Idiotypic Antibodies
Phospholipids
Sulfoglycosphingolipids
Antiphospholipid Syndrome
Nervous System

Keywords

  • Anti-phospholipid antibodies
  • Anti-sulfatide antibodies
  • Dysimmune neuropathy
  • Monoclonal gammopathy

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies. / Matà, Sabrina; Grazia Giudizi, Maria; Totaro, Maria; Grippo, Antonello; Fedi, Sandra; Sorbi, Sandro.

In: Journal of Neuroimmunology, Vol. 182, No. 1-2, 01.2007, p. 219-225.

Research output: Contribution to journalArticle

Matà, Sabrina ; Grazia Giudizi, Maria ; Totaro, Maria ; Grippo, Antonello ; Fedi, Sandra ; Sorbi, Sandro. / Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies. In: Journal of Neuroimmunology. 2007 ; Vol. 182, No. 1-2. pp. 219-225.
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