Fine tuning of the temporal expression of HTLV-1 and HTLV-2

Ilaria Cavallari, Francesca Rende, Cecilia Bender, Maria G. Romanelli, Donna M. D'Agostino, Vincenzo Ciminale

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are delta retroviruses that share a common overall genetic organization, splicing pattern, and ability to infect and immortalize T-cells in vitro. However, HTLV-1 and HTLV-2 exhibit a clearly distinct pathogenic potential in infected patients. To find clues to the possible viral determinants of the biology of these viruses, recent studies investigated the timing of expression and the intracellular compartmentalization of viral transcripts in ex-vivo samples from infected patients. Results of these studies revealed a common overall pattern of expression of HTLV-1 and -2 with a two-phase kinetics of expression and a nuclear accumulation of minus-strand transcripts. Studies in cells transfected with HTLV-1 molecular clones demonstrated the strict Rex-dependency of this "two-phase" kinetics. These studies also highlighted interesting differences in the relative abundance of transcripts encoding the Tax and Rex regulatory proteins, and that of the accessory proteins controlling Rex expression and function, thus suggesting a potential basis for the different pathobiology of the two viruses.

Original languageEnglish
JournalFrontiers in Microbiology
Volume4
Issue numberSEP
DOIs
Publication statusPublished - 2013

Fingerprint

Human T-lymphotropic virus 2
Human T-lymphotropic virus 1
rex Gene Products
Viruses
Deltaretrovirus
Retroviridae
Clone Cells
T-Lymphocytes

Keywords

  • HTLV-1
  • HTLV-2
  • Rex
  • Splicing
  • Tax

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Cavallari, I., Rende, F., Bender, C., Romanelli, M. G., D'Agostino, D. M., & Ciminale, V. (2013). Fine tuning of the temporal expression of HTLV-1 and HTLV-2. Frontiers in Microbiology, 4(SEP). https://doi.org/10.3389/fmicb.2013.00235

Fine tuning of the temporal expression of HTLV-1 and HTLV-2. / Cavallari, Ilaria; Rende, Francesca; Bender, Cecilia; Romanelli, Maria G.; D'Agostino, Donna M.; Ciminale, Vincenzo.

In: Frontiers in Microbiology, Vol. 4, No. SEP, 2013.

Research output: Contribution to journalArticle

Cavallari, I, Rende, F, Bender, C, Romanelli, MG, D'Agostino, DM & Ciminale, V 2013, 'Fine tuning of the temporal expression of HTLV-1 and HTLV-2', Frontiers in Microbiology, vol. 4, no. SEP. https://doi.org/10.3389/fmicb.2013.00235
Cavallari, Ilaria ; Rende, Francesca ; Bender, Cecilia ; Romanelli, Maria G. ; D'Agostino, Donna M. ; Ciminale, Vincenzo. / Fine tuning of the temporal expression of HTLV-1 and HTLV-2. In: Frontiers in Microbiology. 2013 ; Vol. 4, No. SEP.
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