Finite element analysis of cancellous bone failure in the vertebral body of healthy and osteoporotic subjects

A. Boccaccio, P. Vena, D. Gastaldi, G. Franzoso, R. Pietrabissa, C. Pappalettere

Research output: Contribution to journalArticle

Abstract

The aim of this work is to assess the fracture risk prediction of the cancellous bone in the body of a lumbar vertebra when the mechanical parameters of the bone, i.e. stiffness, porosity, and strength anisotropy, of elderly and osteoporotic subjects are considered. For this purpose, a non-linear three-dimensional continuum-based finite element model of the lumbar functional spinal unit L4-L5 was created and strength analyses of the spongy tissue of the vertebral body were carried out. A fabric-dependent strength criterion, which accounts for the micro-architecture of the cancellous bone, based on histomorphometric analyses was used. The strength analyses have shown that the cancellous bone of none of the subject types undergoes failure under loading applied during normal daily life like axial compression; however, bone failure occurs for the osteoporotic segment, subjected to a combination of the compression preloading and moments in the sagittal or in the frontal plane, which are conditions that may not be considered to occur 'daily'. In particular, critical stress conditions are met because of the high porosity values in the horizontal direction within the cancellous bone. The computational approach presented in the paper can potentially predict the material fracture risk of the cancellous bone in the vertebral body and it may be usefully employed to draw failure maps representing, for a given micro-architecture of the spongy tissue, the critical loading conditions (forces and moments) that may lead to such a risk. This approach could be further developed in order to assess the effectiveness of biomedical devices within an engineering approach to the clinical problem of the spinal diseases.

Original languageEnglish
Pages (from-to)1023-1036
Number of pages14
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Volume222
Issue number7
DOIs
Publication statusPublished - Oct 1 2008

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Finite Element Analysis
Healthy Volunteers
Bone
Finite element method
Porosity
Spinal Diseases
Bone and Bones
Lumbar Vertebrae
Anisotropy
Tissue
Axial compression
Cancellous Bone
Equipment and Supplies
Stiffness

Keywords

  • finite element analysis
  • fracture criterion
  • lumbar spine
  • osteoporosis
  • soft biological tissues

ASJC Scopus subject areas

  • Mechanical Engineering
  • Medicine(all)

Cite this

Finite element analysis of cancellous bone failure in the vertebral body of healthy and osteoporotic subjects. / Boccaccio, A.; Vena, P.; Gastaldi, D.; Franzoso, G.; Pietrabissa, R.; Pappalettere, C.

In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Vol. 222, No. 7, 01.10.2008, p. 1023-1036.

Research output: Contribution to journalArticle

Boccaccio, A. ; Vena, P. ; Gastaldi, D. ; Franzoso, G. ; Pietrabissa, R. ; Pappalettere, C. / Finite element analysis of cancellous bone failure in the vertebral body of healthy and osteoporotic subjects. In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2008 ; Vol. 222, No. 7. pp. 1023-1036.
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