First case of transformation for breast fibroadenoma to high-grade malignant cystosarcoma in an in vitro fertilization patient

Arianna Pacchiarotti, Paola Frati, Donatella Caserta, Alessandro Pacchiarotti, Antonio Frega, Massimo Moscarini

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the possible malignant transformation of fibroadenoma of the breast in patients undergoing an IVF cycle. Design: Case report. Setting: Assisted reproduction center. Patient(s): A 41-year-old female patient undergoing assisted fertilization treatment. Intervention(s): The patient underwent fine needle aspiration biopsy that confirmed fibroadenoma before the IVF attempt. She started a short stimulation protocol with triptorelin and recombinant FSH. After the first unsuccessful IVF attempt, she underwent a second short ovarian stimulation protocol with triptorelin and urinary FSH and she become pregnant. At 17 weeks, due to an increase in volume of the fibroadenoma, an excisional biopsy was performed that showed a malignant phyllode tumor. Then she underwent quadrantectomy. Main Outcome Measure(s): Malignant transformation of breast fibroadenoma. Result(s): Cytologic examination of the first fine needle aspiration biopsy specimen showed a fibroadenoma of the breast; excisional biopsy showed a high-grade malignant cystosarcoma. Conclusion(s): Fibroadenoma was transformed into high-grade malignant cystosarcoma after ovarian stimulation in an IVF patient.

Original languageEnglish
Pages (from-to)1126-1127
Number of pages2
JournalFertility and Sterility
Volume96
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Cystosarcoma phyllode
  • fibroadenoma
  • IVF
  • phyllode tumour

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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