First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature.

A. Pacchiarotti, H. Selman, V. Gentile, A. Pacchiarotti, G. N. Milazzo, G. Lanzilotti, S. Lofino, P. Frati

Research output: Contribution to journalArticlepeer-review

Abstract

Cystosarcoma phyllodes are very rare tumors and may be difficult to diagnose clinically. Fibroadenomas have long been considered benign hyperplastic lesions rather than true neoplastic processes. However, previous clonality studies have shown differing results. to assess diagnostic and treatment options for phyllodes tumor. A 41-year-old female patient undergoing assisted fertilization treatment. The patient underwent fine needle aspiration biopsy that confirmed fibroadenoma before the IVF attempt. At 17 weeks of gestation, due to an increase in volume of the fibroadenoma, an excisional biopsy was performer that showed a malignant phyllodes tumor. Then she underwent quadrantectomy and chemiotherapy After 1 year there was a recurrence of phyllodes tumors and she underwent mastectomy and chemotherapy. Fibroadenoma that was transformed into high-grade malignant cystosarcoma after ovarian stimulation, relapsed after one year and it was not immediately diagnosed. The patient underwent mastectomy and chemotherapy. it is difficult to diagnose recurrence and to determine tele frequency and the right treatment for such a rare cancer, so it is important to report any case in the literature. We recommend to remove a fibroadenoma before attempting IVF for the risk of malignant transformation.

Original languageEnglish
Pages (from-to)2495-2498
Number of pages4
JournalEuropean Review for Medical and Pharmacological Sciences
Volume17
Issue number18
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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