Primer caso de fungemia asociada a catéter por Candida nivariensis en la Península Ibérica

Translated title of the contribution: First case report of catheter-related fungemia by Candida nivariensis in the Iberian Peninsula

Leyre M. López-Soria, Elena Bereciartua, Marta Santamaría, Luis Miguel Soria, José Luis Hernández-Almaraz, Alessandra Mularoni, Javier Nieto, Miguel Montejo

Research output: Contribution to journalArticle

Abstract

Background: In recent years the incidence of candidemia caused by non-albicans Candida species has been increasing. Two cryptic species have been described within the Candida glabrata complex, Candida nivariensis and Candida bracarensis, which may be troublesome in laboratory identification and have lower susceptibility to fluconazole. Aims: To describe the first isolation of C. nivariensis in the Iberian Peninsula from a patient suffering from a catheter-related fungemia. Case report: An 81-year-old man was hospitalized for surgical treatment of an intestinal fistula that was associated to a severe malnutrition. Cultures of the patient's central venous catheter tip and blood yielded white colonies in BD CHROMagar Candida® medium, which could not be identified by conventional microbiological methods. Although intravenous fluconazole was administered, blood cultures continued being positive 5 days later. The MIC values of the isolate were as follows: 1μg/ml for amphotericin B, 0.015μg/ml for anidulafungin, 0.125μg/ml for caspofungin, 0.015μg/ml for micafungin, 4μg/ml for fluconazole, 0.25μg/ml for itraconazole, 0.25μg/ml for posaconazole, and 0.03μg/ml for voriconazole. Antifungal treatment was changed to intravenous caspofungin for 2 weeks. The intestinal fistula was surgically treated. There was no evidence of relapse during the following month, and the patient was discharged. The isolate was identified as C. nivariensis based on DNA sequencing of the ITS regions of rRNA. Conclusions: C. nivariensis should be regarded as an emerging pathogen which requires molecular methods for a definitive identification. Our patient was successfully treated with caspofungin.

Translated title of the contributionFirst case report of catheter-related fungemia by Candida nivariensis in the Iberian Peninsula
Original languageSpanish
Pages (from-to)69-71
Number of pages3
JournalRevista Iberoamericana de Micologia
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 3 2013

Keywords

  • Candida nivariensis
  • Candidemia
  • Caspofungin
  • Catheter
  • Fluconazole
  • Fungemia

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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