TY - JOUR
T1 - First-cycle REM density in never-depressed subjects with borderline personality disorder
AU - Battaglia, Marco
AU - Strambi, Luigi Ferini
AU - Bertella, Silvana
AU - Bajo, Sonia
AU - Bellodi, Laura
PY - 1999/4/15
Y1 - 1999/4/15
N2 - Background: There is much interest in the identification of polysomnographic markers of liability to the mood disorders that may predate the onset of illness in high-risk subjects, and/or remain altered after remission. One such putative marker is rapid eye movement (REM) density during the first REM period Methods: Never-depressed subjects with borderline personality disorder (BPD) as a group at high risk for the mood disorders were compared by continuous 48-hour ambulatory eIectroencephalographic monitoring to age- and gender-matched controls. Results: Subjects with BPD had significantly higher REM density during the first REM period. One man with BPD who later committed suicide had REM density values exceeding the mean value of his group by 2 SD. Conclusions: These data extend the view that REM density in the first REM period can be a marker of liability to the mood disorders, as it is present in a group of young subjects at heightened risk for depression.
AB - Background: There is much interest in the identification of polysomnographic markers of liability to the mood disorders that may predate the onset of illness in high-risk subjects, and/or remain altered after remission. One such putative marker is rapid eye movement (REM) density during the first REM period Methods: Never-depressed subjects with borderline personality disorder (BPD) as a group at high risk for the mood disorders were compared by continuous 48-hour ambulatory eIectroencephalographic monitoring to age- and gender-matched controls. Results: Subjects with BPD had significantly higher REM density during the first REM period. One man with BPD who later committed suicide had REM density values exceeding the mean value of his group by 2 SD. Conclusions: These data extend the view that REM density in the first REM period can be a marker of liability to the mood disorders, as it is present in a group of young subjects at heightened risk for depression.
KW - Borderline personality disorder
KW - Mood disorders
KW - Polysomnography
KW - REM sleep
KW - Vulnerability markers
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U2 - 10.1016/S0006-3223(98)00213-3
DO - 10.1016/S0006-3223(98)00213-3
M3 - Article
C2 - 10386191
AN - SCOPUS:0033561028
VL - 45
SP - 1056
EP - 1058
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 8
ER -