First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: A case report

Carla B. Ripamonti, Mara Colombo, Patrizia Mondini, Manoukian Siranoush, Bernard Peissel, Loris Bernard, Paolo Radice, Maria Luisa Carcangiu

Research output: Contribution to journalArticle

Abstract

Background: Acinic cell carcinoma (ACC) is a rare malignant epithelial neoplasm characterized by the presence of malignant tubular acinar exocrine gland structures. Diagnosis is generally made in salivary glands and in the pancreas. ACC of the breast has been reported in few cases only. Carriers of inherited mutations in the BRCA1 gene are prone to the development of breast cancer, mainly invasive ductal or medullary type carcinomas. We describe for the first time a BRCA1 mutation carrier with a diagnosis of ACC of the breast.Case presentation: The patient developed an invasive ductal carcinoma (IDC) at the age of 40 years and an ACC in the contralateral breast at 44 years. Immunohistochemical examination of the ACC revealed a triple negative status (i.e., negativity for estrogen receptor, progesterone receptor and HER2 protein) and positivity for p53. Using a combination of loss of heterozygosity (LOH) and sequencing analyses, the loss of the wild-type BRCA1 allele was detected in both the ACC and the IDC. In addition, two different somatic TP53 mutations, one in the ACC only and another one in the IDC only, were observed.Conclusion: Both the immunohistochemical and molecular features observed in the ACC are typical of BRCA1-associated breast cancers and suggest an involvement of the patient's germline mutation in the disease. The occurrence of rare histological types of breast cancers, including malignant phyllodes tumor, atypical medullary carcinoma and metaplastic carcinoma, in BRCA1 mutation carriers has been already reported. Our findings further broaden the spectrum of BRCA1-associated breast malignancies.

Original languageEnglish
Article number46
JournalBMC Cancer
Volume13
DOIs
Publication statusPublished - Feb 1 2013

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Acinar Cell Carcinoma
Breast
Mutation
Ductal Carcinoma
Medullary Carcinoma
Breast Neoplasms
Exocrine Glands
Phyllodes Tumor
BRCA1 Gene
Carcinoma
Germ-Line Mutation
Loss of Heterozygosity
Progesterone Receptors
Salivary Glands
Estrogen Receptors
Pancreas
Alleles

Keywords

  • Acinic cell carcinoma
  • BRCA1
  • Breast cancer
  • TP53 mutation
  • Triple negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier : A case report. / Ripamonti, Carla B.; Colombo, Mara; Mondini, Patrizia; Siranoush, Manoukian; Peissel, Bernard; Bernard, Loris; Radice, Paolo; Carcangiu, Maria Luisa.

In: BMC Cancer, Vol. 13, 46, 01.02.2013.

Research output: Contribution to journalArticle

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