First endocavitary treatment with cord blood platelet gel for perianal fistula

Giovanni Bisceglia; Michele Santodirocco; Augusta Faienza; Nicola Mastrodonato; Filomena Urbano; Angela Totaro; Francesca Bazzocchi; Lazzaro Di Mauro

doi:10.2217/rme-2019-0074

First endocavitary treatment with cord blood platelet gel for perianal fistula

Giovanni Bisceglia, Michele Santodirocco, Augusta Faienza, Nicola Mastrodonato, Filomena Urbano, Angela Totaro, Francesca Bazzocchi, Lazzaro Di Mauro

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article

Abstract

Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics and developed an application technique of platelet gel in liquid form. This semi-activated form provides for the activation of the coagulation process but not the gelification of the platelet concentrate. In this way, it can be easily inoculated in an endocavitary space, and then complete in vivo the gelification process. We report the successful use of this procedure to heal a recurrent perianal fistula.

Original language	English
Pages (from-to)	1171-1176
Number of pages	6
Journal	Regenerative Medicine
Volume	15
Issue number	1
DOIs	https://doi.org/10.2217/rme-2019-0074
Publication status	Published - Jan 2020

Keywords

cord blood
hematology
regeneration
repair
skin and wound care

ASJC Scopus subject areas

Biomedical Engineering
Embryology

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Bisceglia, G., Santodirocco, M., Faienza, A., Mastrodonato, N., Urbano, F., Totaro, A., Bazzocchi, F., & Mauro, L. D. (2020). First endocavitary treatment with cord blood platelet gel for perianal fistula. Regenerative Medicine, 15(1), 1171-1176. https://doi.org/10.2217/rme-2019-0074

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AU - Totaro, Angela

AU - Bazzocchi, Francesca

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