TY - JOUR
T1 - First endocavitary treatment with cord blood platelet gel for perianal fistula
AU - Bisceglia, Giovanni
AU - Santodirocco, Michele
AU - Faienza, Augusta
AU - Mastrodonato, Nicola
AU - Urbano, Filomena
AU - Totaro, Angela
AU - Bazzocchi, Francesca
AU - Mauro, Lazzaro Di
PY - 2020/1
Y1 - 2020/1
N2 - Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics and developed an application technique of platelet gel in liquid form. This semi-activated form provides for the activation of the coagulation process but not the gelification of the platelet concentrate. In this way, it can be easily inoculated in an endocavitary space, and then complete in vivo the gelification process. We report the successful use of this procedure to heal a recurrent perianal fistula.
AB - Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics and developed an application technique of platelet gel in liquid form. This semi-activated form provides for the activation of the coagulation process but not the gelification of the platelet concentrate. In this way, it can be easily inoculated in an endocavitary space, and then complete in vivo the gelification process. We report the successful use of this procedure to heal a recurrent perianal fistula.
KW - cord blood
KW - hematology
KW - regeneration
KW - repair
KW - skin and wound care
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U2 - 10.2217/rme-2019-0074
DO - 10.2217/rme-2019-0074
M3 - Article
C2 - 32046600
AN - SCOPUS:85082143769
VL - 15
SP - 1171
EP - 1176
JO - Regenerative Medicine
JF - Regenerative Medicine
SN - 1746-0751
IS - 1
ER -