First epidemiological and phylogenetic analysis of Hepatitis B virus infection in migrants from Mali

on behalf of the Sanitary Bureau of Asylum Seekers Center of Castelnuovo di Porto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The armed conflict in Mali caused a migration crisis since 2012. Most Malian refugees were in Italy. In Sub-Saharan Africa, the seroprevalence of anti-HBV antibodies is particularly high. Genotype E is the most prevalent throughout a crescent covering area from Angola to Senegal, including Mali. We report 16 HBV positive individual from 136 Malian asylum seekers in order to investigate the genetic diversity of HBV in this population. Sequencing and phylogenetic analysis has been used. The HBV genotype E isolates from Mali did not cluster together but were intermixed, with the other African sequences. Only three supported clade were evidenced and closely related to sequences from Burkina Faso. The estimated evolutionary rate was 9.29 � 104. The root of the tree dated back to February 2008 in (95% HPD: 2006–2011). From this ancestor six main statistically supported clusters (pp > 0.80) were identified. The most recent Clade dated back to May 2015. The BSP showed that the effective number of infections softly increased from 2011 to the 2015. Phylogenetic analysis helped in understanding how two on sixteen individuals, have been infected in Italy, and give an important improvement in prevention campaigns and monitoring of the viral infection in migrants. J. Med. Virol. 89:639–646, 2017. � 2016 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalJournal of Medical Virology
Volume89
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

Mali
Virus Diseases
Hepatitis B virus
Refugees
Italy
Angola
Genotype
Burkina Faso
Senegal
Africa South of the Sahara
Seroepidemiologic Studies
Anti-Idiotypic Antibodies
Infection
Population

Keywords

  • epidemiology
  • evolution
  • Hepatitis B virus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

on behalf of the Sanitary Bureau of Asylum Seekers Center of Castelnuovo di Porto (2017). First epidemiological and phylogenetic analysis of Hepatitis B virus infection in migrants from Mali. Journal of Medical Virology, 89(4), 639-646. https://doi.org/10.1002/jmv.24671

First epidemiological and phylogenetic analysis of Hepatitis B virus infection in migrants from Mali. / on behalf of the Sanitary Bureau of Asylum Seekers Center of Castelnuovo di Porto.

In: Journal of Medical Virology, Vol. 89, No. 4, 01.04.2017, p. 639-646.

Research output: Contribution to journalArticle

on behalf of the Sanitary Bureau of Asylum Seekers Center of Castelnuovo di Porto 2017, 'First epidemiological and phylogenetic analysis of Hepatitis B virus infection in migrants from Mali', Journal of Medical Virology, vol. 89, no. 4, pp. 639-646. https://doi.org/10.1002/jmv.24671
on behalf of the Sanitary Bureau of Asylum Seekers Center of Castelnuovo di Porto. First epidemiological and phylogenetic analysis of Hepatitis B virus infection in migrants from Mali. Journal of Medical Virology. 2017 Apr 1;89(4):639-646. https://doi.org/10.1002/jmv.24671
on behalf of the Sanitary Bureau of Asylum Seekers Center of Castelnuovo di Porto. / First epidemiological and phylogenetic analysis of Hepatitis B virus infection in migrants from Mali. In: Journal of Medical Virology. 2017 ; Vol. 89, No. 4. pp. 639-646.
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abstract = "The armed conflict in Mali caused a migration crisis since 2012. Most Malian refugees were in Italy. In Sub-Saharan Africa, the seroprevalence of anti-HBV antibodies is particularly high. Genotype E is the most prevalent throughout a crescent covering area from Angola to Senegal, including Mali. We report 16 HBV positive individual from 136 Malian asylum seekers in order to investigate the genetic diversity of HBV in this population. Sequencing and phylogenetic analysis has been used. The HBV genotype E isolates from Mali did not cluster together but were intermixed, with the other African sequences. Only three supported clade were evidenced and closely related to sequences from Burkina Faso. The estimated evolutionary rate was 9.29 {\"i}¿½ 104. The root of the tree dated back to February 2008 in (95{\%} HPD: 2006–2011). From this ancestor six main statistically supported clusters (pp > 0.80) were identified. The most recent Clade dated back to May 2015. The BSP showed that the effective number of infections softly increased from 2011 to the 2015. Phylogenetic analysis helped in understanding how two on sixteen individuals, have been infected in Italy, and give an important improvement in prevention campaigns and monitoring of the viral infection in migrants. J. Med. Virol. 89:639–646, 2017. {\"i}¿½ 2016 Wiley Periodicals, Inc.",
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