First evidence of in vivo pro-angiogenic activity of cerebrospinal fluid samples from multiple sclerosis patients

Domenico Ribatti, Pietro Iaffaldano, Christian Marinaccio, Maria Trojano

Research output: Contribution to journalArticlepeer-review

Abstract

Increased vascular density and endothelial cell proliferation have been demonstrated in multiple sclerosis (MS) white matter, as well as an elevated vascular endothelial growth factor expression was detected in reactive astrocytes of both active and inactive chronic demyelinated lesions and in sera of MS patients during clinical relapses. In this study, we have investigated the angiogenic activity of cerebrospinal fluid (CSF) samples from MS patients with different stages of disease by means of the chick embryo chorioallantoic membrane (CAM), a well-known assay to study angiogenesis in vivo. Results have shown that CSF samples from MS patients induced a significant (p 

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalClinical and Experimental Medicine
Volume16
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Angiogenesis
  • Cerebrospinal fluid
  • Chorioallantoic membrane
  • Multiple sclerosis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'First evidence of in vivo pro-angiogenic activity of cerebrospinal fluid samples from multiple sclerosis patients'. Together they form a unique fingerprint.

Cite this