First ex vivo validation of a radioguided surgery technique with β-radiation

Elena Solfaroli Camillocci, Marco Paolo Schiariti, V. Bocci, Angela Carollo, Giacomo Chiodi, Marzia Colandrea, Francesco Collamati, Marta Cremonesi, R. Donnarumma, Mahila Esmeralda Ferrari, Paolo Ferroli, Francesco Ghielmetti, Chiara Maria Grana, C. Mancini Terracciano, Michela Marafini, Silvio Morganti, Monica Patanè, Guido Pedroli, Bianca Pollo, Luigi RecchiaAndrea Russomando, M. Toppi, G. Traini, R. Faccini

Research output: Contribution to journalArticle

Abstract

Purpose A radio-guided surgery technique with β-emitting radio-tracers was suggested to overcome the effect of the large penetration of γ radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection. Methods A patient affected by meningioma was administered 300 MBq of 90Y-DOTATOC. Several samples extracted from the meningioma and the nearby Dura Mater were analyzed with a β probe designed specifically for this radio-guided surgery technique. The observed signals were compared both with the evaluation from the histology and with the Monte Carlo simulation. Results we obtained a large signal on the bulk tumor (105 cps) and a significant signal on residuals of ∼0.2 ml (28 cps). We also show that simulations predict correctly the observed yields and this allows us to estimate that the healthy tissues would return negligible signals (≈1 cps). This test also demonstrated that the exposure of the medical staff is negligible and that among the biological wastes only urine has a significant activity. Conclusions This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct.

Original languageEnglish
Pages (from-to)1139-1144
Number of pages6
JournalPhysica Medica
Volume32
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

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Keywords

  • Brain tumors
  • Intraoperative imaging
  • Radio-guided-surgery
  • β-decays

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

Camillocci, E. S., Schiariti, M. P., Bocci, V., Carollo, A., Chiodi, G., Colandrea, M., Collamati, F., Cremonesi, M., Donnarumma, R., Ferrari, M. E., Ferroli, P., Ghielmetti, F., Grana, C. M., Mancini Terracciano, C., Marafini, M., Morganti, S., Patanè, M., Pedroli, G., Pollo, B., ... Faccini, R. (2016). First ex vivo validation of a radioguided surgery technique with β-radiation. Physica Medica, 32(9), 1139-1144. https://doi.org/10.1016/j.ejmp.2016.08.018