First experience on bilirubin removal with a hemoadsorption column (Lixelle®) in a child with cardiogenic liver injury

Gabriella Bottari, Andrea Moscatelli, Enrico E Verrina, Franco Lerzo, Fabio S Taccone

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Hyperbilirubinemia may have deleterious effects on many organs, even after the neonatal age. Blood purification is effective in the treatment of hyperbilirubinemia. Recently some reports suggest the potential role of hemoadsorption columns in this setting.

METHODS: We present the case of a 6-year-old child with severe hyperbilirubinemia due to congestive liver dysfunction, complicated by persistent inflammation, immunosuppression and catabolism syndrome (PICS). The patient was treated with a hemoadsorption column (Lixelle®) in combination with continuous veno-venous hemodiafiltration (CVVHDF).

RESULTS: During treatment, a significant and rapid decrease in total bilirubin (TB) and other indices of cholestasis was observed. Furthermore, a progressive reduction in the inflammatory biomarkers (Procalcitonin, C-reactive protein) occurred. These results persisted at the discontinuation of therapy.

CONCLUSIONS: To our knowledge this is the first case in which hemoadsorption with the Lixelle® adsorbing column in combination with CVVHDF has been used to manage pediatric hyperbiliribinemia secondary to cardiogenic liver injury.

Original languageEnglish
Pages (from-to)522-525
Number of pages4
JournalInternational Journal of Artificial Organs
Volume40
Issue number9
DOIs
Publication statusPublished - Sep 15 2017

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Hyperbilirubinemia
Bilirubin
Liver
Hemodiafiltration
Pediatrics
Wounds and Injuries
Calcitonin
Biomarkers
C-Reactive Protein
Purification
Blood
Cholestasis
Proteins
Immunosuppression
Liver Diseases
Therapeutics
Inflammation

Keywords

  • Journal Article

Cite this

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title = "First experience on bilirubin removal with a hemoadsorption column (Lixelle{\circledR}) in a child with cardiogenic liver injury",
abstract = "INTRODUCTION: Hyperbilirubinemia may have deleterious effects on many organs, even after the neonatal age. Blood purification is effective in the treatment of hyperbilirubinemia. Recently some reports suggest the potential role of hemoadsorption columns in this setting.METHODS: We present the case of a 6-year-old child with severe hyperbilirubinemia due to congestive liver dysfunction, complicated by persistent inflammation, immunosuppression and catabolism syndrome (PICS). The patient was treated with a hemoadsorption column (Lixelle{\circledR}) in combination with continuous veno-venous hemodiafiltration (CVVHDF).RESULTS: During treatment, a significant and rapid decrease in total bilirubin (TB) and other indices of cholestasis was observed. Furthermore, a progressive reduction in the inflammatory biomarkers (Procalcitonin, C-reactive protein) occurred. These results persisted at the discontinuation of therapy.CONCLUSIONS: To our knowledge this is the first case in which hemoadsorption with the Lixelle{\circledR} adsorbing column in combination with CVVHDF has been used to manage pediatric hyperbiliribinemia secondary to cardiogenic liver injury.",
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T1 - First experience on bilirubin removal with a hemoadsorption column (Lixelle®) in a child with cardiogenic liver injury

AU - Bottari, Gabriella

AU - Moscatelli, Andrea

AU - Verrina, Enrico E

AU - Lerzo, Franco

AU - Taccone, Fabio S

PY - 2017/9/15

Y1 - 2017/9/15

N2 - INTRODUCTION: Hyperbilirubinemia may have deleterious effects on many organs, even after the neonatal age. Blood purification is effective in the treatment of hyperbilirubinemia. Recently some reports suggest the potential role of hemoadsorption columns in this setting.METHODS: We present the case of a 6-year-old child with severe hyperbilirubinemia due to congestive liver dysfunction, complicated by persistent inflammation, immunosuppression and catabolism syndrome (PICS). The patient was treated with a hemoadsorption column (Lixelle®) in combination with continuous veno-venous hemodiafiltration (CVVHDF).RESULTS: During treatment, a significant and rapid decrease in total bilirubin (TB) and other indices of cholestasis was observed. Furthermore, a progressive reduction in the inflammatory biomarkers (Procalcitonin, C-reactive protein) occurred. These results persisted at the discontinuation of therapy.CONCLUSIONS: To our knowledge this is the first case in which hemoadsorption with the Lixelle® adsorbing column in combination with CVVHDF has been used to manage pediatric hyperbiliribinemia secondary to cardiogenic liver injury.

AB - INTRODUCTION: Hyperbilirubinemia may have deleterious effects on many organs, even after the neonatal age. Blood purification is effective in the treatment of hyperbilirubinemia. Recently some reports suggest the potential role of hemoadsorption columns in this setting.METHODS: We present the case of a 6-year-old child with severe hyperbilirubinemia due to congestive liver dysfunction, complicated by persistent inflammation, immunosuppression and catabolism syndrome (PICS). The patient was treated with a hemoadsorption column (Lixelle®) in combination with continuous veno-venous hemodiafiltration (CVVHDF).RESULTS: During treatment, a significant and rapid decrease in total bilirubin (TB) and other indices of cholestasis was observed. Furthermore, a progressive reduction in the inflammatory biomarkers (Procalcitonin, C-reactive protein) occurred. These results persisted at the discontinuation of therapy.CONCLUSIONS: To our knowledge this is the first case in which hemoadsorption with the Lixelle® adsorbing column in combination with CVVHDF has been used to manage pediatric hyperbiliribinemia secondary to cardiogenic liver injury.

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VL - 40

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JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

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