First-generation antipsychotics and QTc: any role for mediating variables?

Giuseppe Carrà; Cristina Crocamo; Francesco Bartoli; Annamaria Lax; Martina Tremolada; Claudio Lucii; Giovanni Martinotti; Michela Nosè; Irene Bighelli; Giovanni Ostuzzi; Mariasole Castellazzi; Massimo Clerici; Corrado Barbui; Tiziano Acciavatti; A. Adamo; A. Aguglia; C. Albanese; S. Baccaglini; Francesco Bardicchia; R. Barone; Y. Barone; F. Bartoli; C. Bergamini; F. Bertolini; I. Bighelli; S. Bolognesi; A. Bordone; P. Bortolaso; M. Bugliani; C. Calandra; Salvatore Calò; G. Cardamone; M. Caroleo; E. Carra; G. Carrà; D. Carretta; Massimiliano Castellazzi; L. Chiocchi; E. Cinosi; M. Clerici; M. Corbo; E. Corsi; R. Costanzo; G. Costoloni; F. D’Arienzo; S. Debolini; A. De Capua; W. A. Di Napoli; M. Dinelli; E. Facchi; F. Fargnoli; F. Fiori; A. Franchi; F. Gardellin; Chiara Gastaldon; E. Gazzoletti; Lucio Ghio; M. Giacomin; Manuela Gregis; N. Iovieno; D. Koukouna; A. Lax; Camilla Lintas; A. Luca; M. Luca; C. Lucii; M. Lussetti; M. Madrucci; N. Magnani; L. Magni; Laura Rosa Magni; G. Martinotti; C. Martorelli; R. Mattafirri; M. Nosè; G. Ostuzzi; C. Paladini; Davide Papola; M. Percudani; G. Perini; P. Petrosemolo; M. Pezzullo; S. Piantanida; Federica Pinna; K. Prato; D. Prestia; Diego Quattrone; C. Reggianini; F. Restaino; M. Ribolsi; Michele Ribolsi; Carla Rizzo; Raffella Rizzo; M. Roggi; Giovanni Rossi; Giuseppe Rossi; S. Ruberto; M. Santi; R. Santoro; Gianna Sepede; Maria Signorelli; F. Soscia; F. Sozzi; P. Staffa; M. Stilo; Stefania Strizzolo; F. Suraniti; N. Tavian; L. Tortelli; F. Tosoni; M. Valdagno; V. Zanobini; C. Barbui

doi:10.1002/hup.2540

First-generation antipsychotics and QTc: any role for mediating variables?

Giuseppe Carrà, Cristina Crocamo, Francesco Bartoli, Annamaria Lax, Martina Tremolada, Claudio Lucii, Giovanni Martinotti, Michela Nosè, Irene Bighelli, Giovanni Ostuzzi, Mariasole Castellazzi, Massimo Clerici, Corrado Barbui, Tiziano Acciavatti, A. Adamo, A. Aguglia, C. Albanese, S. Baccaglini, Francesco Bardicchia, R. BaroneY. Barone, F. Bartoli, C. Bergamini, F. Bertolini, I. Bighelli, S. Bolognesi, A. Bordone, P. Bortolaso, M. Bugliani, C. Calandra, Salvatore Calò, G. Cardamone, M. Caroleo, E. Carra, G. Carrà, D. Carretta, Massimiliano Castellazzi, L. Chiocchi, E. Cinosi, M. Clerici, M. Corbo, E. Corsi, R. Costanzo, G. Costoloni, F. D’Arienzo, S. Debolini, A. De Capua, W. A. Di Napoli, M. Dinelli, E. Facchi, F. Fargnoli, F. Fiori, A. Franchi, F. Gardellin, Chiara Gastaldon, E. Gazzoletti, Lucio Ghio, M. Giacomin, Manuela Gregis, N. Iovieno, D. Koukouna, A. Lax, Camilla Lintas, A. Luca, M. Luca, C. Lucii, M. Lussetti, M. Madrucci, N. Magnani, L. Magni, Laura Rosa Magni, G. Martinotti, C. Martorelli, R. Mattafirri, M. Nosè, G. Ostuzzi, C. Paladini, Davide Papola, M. Percudani, G. Perini, P. Petrosemolo, M. Pezzullo, S. Piantanida, Federica Pinna, K. Prato, D. Prestia, Diego Quattrone, C. Reggianini, F. Restaino, M. Ribolsi, Michele Ribolsi, Carla Rizzo, Raffella Rizzo, M. Roggi, Giovanni Rossi, Giuseppe Rossi, S. Ruberto, M. Santi, R. Santoro, Gianna Sepede, Maria Signorelli, F. Soscia, F. Sozzi, P. Staffa, M. Stilo, Stefania Strizzolo, F. Suraniti, N. Tavian, L. Tortelli, F. Tosoni, M. Valdagno, V. Zanobini, C. Barbui

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	313-318
Number of pages	6
Journal	Human Psychopharmacology
DOIs	https://doi.org/10.1002/hup.2540
Publication status	Published - Jul 1 2016

Keywords

alcohol
antipsychotic agents
drug therapy combination
QT prolongation
risk factors

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

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10.1002/hup.2540

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Carrà, G., Crocamo, C., Bartoli, F., Lax, A., Tremolada, M., Lucii, C., Martinotti, G., Nosè, M., Bighelli, I., Ostuzzi, G., Castellazzi, M., Clerici, M., Barbui, C., Acciavatti, T., Adamo, A., Aguglia, A., Albanese, C., Baccaglini, S., Bardicchia, F., ... Barbui, C. (2016). First-generation antipsychotics and QTc: any role for mediating variables? Human Psychopharmacology, 313-318. https://doi.org/10.1002/hup.2540

Carrà, G, Crocamo, C, Bartoli, F, Lax, A, Tremolada, M, Lucii, C, Martinotti, G, Nosè, M, Bighelli, I, Ostuzzi, G, Castellazzi, M, Clerici, M, Barbui, C, Acciavatti, T, Adamo, A, Aguglia, A, Albanese, C, Baccaglini, S, Bardicchia, F, Barone, R, Barone, Y, Bartoli, F, Bergamini, C, Bertolini, F, Bighelli, I, Bolognesi, S, Bordone, A, Bortolaso, P, Bugliani, M, Calandra, C, Calò, S, Cardamone, G, Caroleo, M, Carra, E, Carrà, G, Carretta, D, Castellazzi, M, Chiocchi, L, Cinosi, E, Clerici, M, Corbo, M, Corsi, E, Costanzo, R, Costoloni, G, D’Arienzo, F, Debolini, S, De Capua, A, Di Napoli, WA, Dinelli, M, Facchi, E, Fargnoli, F, Fiori, F, Franchi, A, Gardellin, F, Gastaldon, C, Gazzoletti, E, Ghio, L, Giacomin, M, Gregis, M, Iovieno, N, Koukouna, D, Lax, A, Lintas, C, Luca, A, Luca, M, Lucii, C, Lussetti, M, Madrucci, M, Magnani, N, Magni, L, Magni, LR, Martinotti, G, Martorelli, C, Mattafirri, R, Nosè, M, Ostuzzi, G, Paladini, C, Papola, D, Percudani, M, Perini, G, Petrosemolo, P, Pezzullo, M, Piantanida, S, Pinna, F, Prato, K, Prestia, D, Quattrone, D, Reggianini, C, Restaino, F, Ribolsi, M, Ribolsi, M, Rizzo, C, Rizzo, R, Roggi, M, Rossi, G, Rossi, G, Ruberto, S, Santi, M, Santoro, R, Sepede, G, Signorelli, M, Soscia, F, Sozzi, F, Staffa, P, Stilo, M, Strizzolo, S, Suraniti, F, Tavian, N, Tortelli, L, Tosoni, F, Valdagno, M, Zanobini, V & Barbui, C 2016, 'First-generation antipsychotics and QTc: any role for mediating variables?', Human Psychopharmacology, pp. 313-318. https://doi.org/10.1002/hup.2540

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title = "First-generation antipsychotics and QTc: any role for mediating variables?",

abstract = "Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright {\textcopyright} 2016 John Wiley & Sons, Ltd.",

keywords = "alcohol, antipsychotic agents, drug therapy combination, QT prolongation, risk factors",

author = "Giuseppe Carr{\`a} and Cristina Crocamo and Francesco Bartoli and Annamaria Lax and Martina Tremolada and Claudio Lucii and Giovanni Martinotti and Michela Nos{\`e} and Irene Bighelli and Giovanni Ostuzzi and Mariasole Castellazzi and Massimo Clerici and Corrado Barbui and Tiziano Acciavatti and A. Adamo and A. Aguglia and C. Albanese and S. Baccaglini and Francesco Bardicchia and R. Barone and Y. Barone and F. Bartoli and C. Bergamini and F. Bertolini and I. Bighelli and S. Bolognesi and A. Bordone and P. Bortolaso and M. Bugliani and C. Calandra and Salvatore Cal{\`o} and G. Cardamone and M. Caroleo and E. Carra and G. Carr{\`a} and D. Carretta and Massimiliano Castellazzi and L. Chiocchi and E. Cinosi and M. Clerici and M. Corbo and E. Corsi and R. Costanzo and G. Costoloni and F. D{\textquoteright}Arienzo and S. Debolini and {De Capua}, A. and {Di Napoli}, {W. A.} and M. Dinelli and E. Facchi and F. Fargnoli and F. Fiori and A. Franchi and F. Gardellin and Chiara Gastaldon and E. Gazzoletti and Lucio Ghio and M. Giacomin and Manuela Gregis and N. Iovieno and D. Koukouna and A. Lax and Camilla Lintas and A. Luca and M. Luca and C. Lucii and M. Lussetti and M. Madrucci and N. Magnani and L. Magni and Magni, {Laura Rosa} and G. Martinotti and C. Martorelli and R. Mattafirri and M. Nos{\`e} and G. Ostuzzi and C. Paladini and Davide Papola and M. Percudani and G. Perini and P. Petrosemolo and M. Pezzullo and S. Piantanida and Federica Pinna and K. Prato and D. Prestia and Diego Quattrone and C. Reggianini and F. Restaino and M. Ribolsi and Michele Ribolsi and Carla Rizzo and Raffella Rizzo and M. Roggi and Giovanni Rossi and Giuseppe Rossi and S. Ruberto and M. Santi and R. Santoro and Gianna Sepede and Maria Signorelli and F. Soscia and F. Sozzi and P. Staffa and M. Stilo and Stefania Strizzolo and F. Suraniti and N. Tavian and L. Tortelli and F. Tosoni and M. Valdagno and V. Zanobini and C. Barbui",

year = "2016",

month = jul,

day = "1",

doi = "10.1002/hup.2540",

language = "English",

pages = "313--318",

journal = "Human Psychopharmacology",

issn = "0885-6222",

publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - First-generation antipsychotics and QTc

T2 - any role for mediating variables?

AU - Carrà, Giuseppe

AU - Crocamo, Cristina

AU - Bartoli, Francesco

AU - Lax, Annamaria

AU - Tremolada, Martina

AU - Lucii, Claudio

AU - Martinotti, Giovanni

AU - Nosè, Michela

AU - Bighelli, Irene

AU - Ostuzzi, Giovanni

AU - Castellazzi, Mariasole

AU - Clerici, Massimo

AU - Barbui, Corrado

AU - Acciavatti, Tiziano

AU - Adamo, A.

AU - Aguglia, A.

AU - Albanese, C.

AU - Baccaglini, S.

AU - Bardicchia, Francesco

AU - Barone, R.

AU - Barone, Y.

AU - Bartoli, F.

AU - Bergamini, C.

AU - Bertolini, F.

AU - Bighelli, I.

AU - Bolognesi, S.

AU - Bordone, A.

AU - Bortolaso, P.

AU - Bugliani, M.

AU - Calandra, C.

AU - Calò, Salvatore

AU - Cardamone, G.

AU - Caroleo, M.

AU - Carra, E.

AU - Carrà, G.

AU - Carretta, D.

AU - Castellazzi, Massimiliano

AU - Chiocchi, L.

AU - Cinosi, E.

AU - Clerici, M.

AU - Corbo, M.

AU - Corsi, E.

AU - Costanzo, R.

AU - Costoloni, G.

AU - D’Arienzo, F.

AU - Debolini, S.

AU - De Capua, A.

AU - Di Napoli, W. A.

AU - Dinelli, M.

AU - Facchi, E.

AU - Fargnoli, F.

AU - Fiori, F.

AU - Franchi, A.

AU - Gardellin, F.

AU - Gastaldon, Chiara

AU - Gazzoletti, E.

AU - Ghio, Lucio

AU - Giacomin, M.

AU - Gregis, Manuela

AU - Iovieno, N.

AU - Koukouna, D.

AU - Lax, A.

AU - Lintas, Camilla

AU - Luca, A.

AU - Luca, M.

AU - Lucii, C.

AU - Lussetti, M.

AU - Madrucci, M.

AU - Magnani, N.

AU - Magni, L.

AU - Magni, Laura Rosa

AU - Martinotti, G.

AU - Martorelli, C.

AU - Mattafirri, R.

AU - Nosè, M.

AU - Ostuzzi, G.

AU - Paladini, C.

AU - Papola, Davide

AU - Percudani, M.

AU - Perini, G.

AU - Petrosemolo, P.

AU - Pezzullo, M.

AU - Piantanida, S.

AU - Pinna, Federica

AU - Prato, K.

AU - Prestia, D.

AU - Quattrone, Diego

AU - Reggianini, C.

AU - Restaino, F.

AU - Ribolsi, M.

AU - Ribolsi, Michele

AU - Rizzo, Carla

AU - Rizzo, Raffella

AU - Roggi, M.

AU - Rossi, Giovanni

AU - Rossi, Giuseppe

AU - Ruberto, S.

AU - Santi, M.

AU - Santoro, R.

AU - Sepede, Gianna

AU - Signorelli, Maria

AU - Soscia, F.

AU - Sozzi, F.

AU - Staffa, P.

AU - Stilo, M.

AU - Strizzolo, Stefania

AU - Suraniti, F.

AU - Tavian, N.

AU - Tortelli, L.

AU - Tosoni, F.

AU - Valdagno, M.

AU - Zanobini, V.

AU - Barbui, C.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd.

AB - Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd.

KW - alcohol

KW - antipsychotic agents

KW - drug therapy combination

KW - QT prolongation

KW - risk factors

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U2 - 10.1002/hup.2540

DO - 10.1002/hup.2540

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JO - Human Psychopharmacology

JF - Human Psychopharmacology

SN - 0885-6222

ER -

First-generation antipsychotics and QTc: any role for mediating variables?

Abstract

Keywords

ASJC Scopus subject areas

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