First human cerenkography

Antonello Enrico Spinelli, Marco Ferdeghini, Carlo Cavedon, Emanuele Zivelonghi, Riccardo Calandrino, Alberto Fenzi, Andrea Sbarbati, Federico Boschi

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Cerenkov luminescence imaging is an emerging optical preclinical modality based on the detection of Cerenkov radiation induced by beta particles when traveling though biological tissues with a velocity greater than the speed of light. We present the first human Cerenkography obtained by detecting Cerenkov radiation escaping the thyroid gland of a patient treated for hyperthyroidism. The Cerenkov light was detected using an electron multiplied charge coupled device and a conventional C-mount lens. The system set-up has been tested by using a slab of ex vivo tissue equal to a 1 cm slice of chicken breast in order to simulate optical photons attenuation. We then imaged for 2 min the head and neck region of a patient treated orally 24 h before with 550 MBq of I-131. Co-registration between photographic and Cerenkov images showed a good localization of the Cerenkov light within the thyroid region. In conclusion, we showed that it is possible to obtain a planar image of Cerenkov photons escaping from a human tissue. Cerenkography is a potential novel medical tool to image superficial organs of patients treated with beta minus radiopharmaceuticals and can be extended to the imaging of beta plus emitters.

Original languageEnglish
Article number020502
JournalJournal of Biomedical Optics
Volume18
Issue number2
DOIs
Publication statusPublished - 2013

Fingerprint

Cerenkov radiation
Tissue
Photons
thyroid gland
Light velocity
Imaging techniques
Radiation
chickens
beta particles
Radiopharmaceuticals
photons
Charge coupled devices
breast
organs
Luminescence
Lenses
emerging
charge coupled devices
emitters
slabs

Keywords

  • biomedical optics
  • emission
  • luminescence
  • medical imaging

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Spinelli, A. E., Ferdeghini, M., Cavedon, C., Zivelonghi, E., Calandrino, R., Fenzi, A., ... Boschi, F. (2013). First human cerenkography. Journal of Biomedical Optics, 18(2), [020502]. https://doi.org/10.1117/1.JBO.18.2.020502

First human cerenkography. / Spinelli, Antonello Enrico; Ferdeghini, Marco; Cavedon, Carlo; Zivelonghi, Emanuele; Calandrino, Riccardo; Fenzi, Alberto; Sbarbati, Andrea; Boschi, Federico.

In: Journal of Biomedical Optics, Vol. 18, No. 2, 020502, 2013.

Research output: Contribution to journalArticle

Spinelli, AE, Ferdeghini, M, Cavedon, C, Zivelonghi, E, Calandrino, R, Fenzi, A, Sbarbati, A & Boschi, F 2013, 'First human cerenkography', Journal of Biomedical Optics, vol. 18, no. 2, 020502. https://doi.org/10.1117/1.JBO.18.2.020502
Spinelli AE, Ferdeghini M, Cavedon C, Zivelonghi E, Calandrino R, Fenzi A et al. First human cerenkography. Journal of Biomedical Optics. 2013;18(2). 020502. https://doi.org/10.1117/1.JBO.18.2.020502
Spinelli, Antonello Enrico ; Ferdeghini, Marco ; Cavedon, Carlo ; Zivelonghi, Emanuele ; Calandrino, Riccardo ; Fenzi, Alberto ; Sbarbati, Andrea ; Boschi, Federico. / First human cerenkography. In: Journal of Biomedical Optics. 2013 ; Vol. 18, No. 2.
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