First-in-man transcatheter mitral valve-in-ring implantation with a repositionable and retrievable aortic valve prosthesis

Azeem Latib, Neil Ruparelia, Klaudija Bijuklic, Federico De Marco, Fernando Gatto, Lorenz Hansen, Cem Ozbek, Peter Greilach, Giuseppe Bruschi, Friedrich Christian Rieß, Ottavio Alfieri, Antonio Colombo, Joachim Schofer

Research output: Contribution to journalArticle

Abstract

Aims: Transcatheter interventions with balloon-expandable valves have been shown to be efficacious for the treatment of mitral annuloplasty failure but are limited by the fact that there is no opportunity for post-implantation adjustment. The aim of this study was to assess the safety and efficacy of the fully repositionable and retrievable Direct Flow Medical (DFM) valve for the treatment of mitral annuloplasty failure. Methods and results: Patients who underwent transcatheter mitral valve-in-ring (VIR) implantation of a DFM valve for failed mitral annuloplasty deemed high risk for redo surgery were included at four institutions. Eight patients underwent transcatheter mitral VIR procedures with implantation of the DFM valve. The DFM prosthesis was successfully positioned in all patients. Two patients required retrieval of the device due to a suboptimal result, and a further patient required repositioning of the valve with an ultimately successful implantation. During the 30-day follow-up period, two patients died for reasons unrelated to the valve implantation. The four patients with successful implantation had normal valve function associated with a significant improvement in their functional status. Conclusions: For the first time, we demonstrate the safety, efficacy and advantages of using the DFM prosthesis for the treatment of mitral annuloplasty failure.

Original languageEnglish
Pages (from-to)1148-1152
Number of pages5
JournalEuroIntervention
Volume11
Issue number10
DOIs
Publication statusPublished - Feb 1 2016

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Mitral Valve Annuloplasty
Aortic Valve
Mitral Valve
Prostheses and Implants
Moving and Lifting Patients
Safety
Therapeutics
Equipment and Supplies

Keywords

  • Mitral bioprosthesis
  • Transcatheter valve intervention
  • Valve-in-ring

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

First-in-man transcatheter mitral valve-in-ring implantation with a repositionable and retrievable aortic valve prosthesis. / Latib, Azeem; Ruparelia, Neil; Bijuklic, Klaudija; De Marco, Federico; Gatto, Fernando; Hansen, Lorenz; Ozbek, Cem; Greilach, Peter; Bruschi, Giuseppe; Rieß, Friedrich Christian; Alfieri, Ottavio; Colombo, Antonio; Schofer, Joachim.

In: EuroIntervention, Vol. 11, No. 10, 01.02.2016, p. 1148-1152.

Research output: Contribution to journalArticle

Latib, A, Ruparelia, N, Bijuklic, K, De Marco, F, Gatto, F, Hansen, L, Ozbek, C, Greilach, P, Bruschi, G, Rieß, FC, Alfieri, O, Colombo, A & Schofer, J 2016, 'First-in-man transcatheter mitral valve-in-ring implantation with a repositionable and retrievable aortic valve prosthesis', EuroIntervention, vol. 11, no. 10, pp. 1148-1152. https://doi.org/10.4244/EIJY15M11-02
Latib, Azeem ; Ruparelia, Neil ; Bijuklic, Klaudija ; De Marco, Federico ; Gatto, Fernando ; Hansen, Lorenz ; Ozbek, Cem ; Greilach, Peter ; Bruschi, Giuseppe ; Rieß, Friedrich Christian ; Alfieri, Ottavio ; Colombo, Antonio ; Schofer, Joachim. / First-in-man transcatheter mitral valve-in-ring implantation with a repositionable and retrievable aortic valve prosthesis. In: EuroIntervention. 2016 ; Vol. 11, No. 10. pp. 1148-1152.
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