Il trattamento neoadiuvante con chemio-radioterapia di prima linea nei carcinomi epidermoidi localmente avanzati (T4) dell'esofago.

Translated title of the contribution: First-line chemo-radiotherapy neoadjuvant treatment in locally advanced (T4) epidermoid carcinoma of the esophagus

E. Ancona, S. Merigliano, G. Petrin, M. Cagol, S. Scappin, H. Koussis, C. Boso, V. Chiarion Sileni, L. Corti, A. Ruol

Research output: Contribution to journalArticle

Abstract

In the period 1993-1997 we performed two phase II pilot studies of first-line chemo-radiotherapy in patients with locally advanced (T4) SCC of the esophagus. The first protocol (3 cycles of DDP-VP16 + 45 Gy) was used in 37 patients: toxicity was not negligible; a clinical tumor downstaging was obtained in 54% of cases; an R0 resection surgery was performed in 40% of patients. The overall median survival of the whole group of 37 patients was 11 months, while it was > 36 months for patients undergoing R0 resection. The second protocol (4 cycles of DDP-5FU + 45 Gy) was used in 25 patients: a clinical tumor downstaging was obtained in 55% of cases, and R0 resection surgery was performed in 45% of patients. The overall median survival of the whole group was 11 months. To date, all patients but one (who died after 13 months) are alive with a median follow up of 13 months. The prognosis of both groups of patients was improved compared to patients with T4 SCC of the esophagus who did not undergo chemo and/or radiotherapy. The survival advantage was especially evident for those who were able to undergo an R0 resection. First line chemo-radiotherapy should be considered the standard treatment for locally advanced esophageal SCC.

Translated title of the contributionFirst-line chemo-radiotherapy neoadjuvant treatment in locally advanced (T4) epidermoid carcinoma of the esophagus
Original languageItalian
Pages (from-to)91-97
Number of pages7
JournalChirurgia Italiana
Volume51
Issue number2
Publication statusPublished - Mar 1999

ASJC Scopus subject areas

  • Surgery

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