First-Line Liver Resection and Salvage Liver Transplantation Are Increasing Therapeutic Strategies for Patients With Hepatocellular Carcinoma and Child A Cirrhosis

G. Vennarecci, G. M. Ettorre, M. Antonini, R. Santoro, M. Maritti, G. Tacconi, D. Spoletini, L. Tessitore, L. Perracchio, G. Visco, C. Puoti, E. Santoro

Research output: Contribution to journalArticle

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Abstract

Aim: The present study focused on nine patients with hepatocellular carcinoma (HCC) associated with Child A liver cirrhosis undergoing first-line liver resection and salvage liver transplantation (SLT) for liver tumor recurrence. Patients and methods: Forty-six patients with HCC underwent liver transplantation (OLT); 37 (80.5%) were primary liver transplantations (PLTs) and 9 (19.5%) were SLTs. All patients who underwent SLT received minor transabdominal liver resections. Results: The posttransplant 1-, 3-, and 5-year overall survival rates for SLT (88.9%, 88.9%, and 88.9%) were similar to those for PLT (78%, 62.7%, and 62.7%). Four (10.8%) patients in the PLT group had HCC recurrence, while there was zero recurrence in the SLT group. The 1-, 3-, 5-year disease-free survival rates for PLT (89%, 74%, and 74%) were similar to those for SLT (100%, 100%, and 100%). The 1-, 3-, 5-year disease-free survival rates after PLT were 89%, 74%, and 74%, and after SLT were 100%, 100%, and 100%, respectively. The operative mortality, intraperioperative bleeding, operative time, intensive care unit stay, in-hospital stay, and overall incidence of postoperative complications were similar in the two groups. Conclusions: In our experience, SLT for HCC is a feasible procedure with similar results in terms of overall survival, disease-free survival, and postoperative complications to those reported for patients who underwent PLT at our institute. An important role exists for SLT as shown by the fact that such a strategy has been used in the 20% of the patients undergoing OLT for HCC.

Original languageEnglish
Pages (from-to)1857-1860
Number of pages4
JournalTransplantation Proceedings
Volume39
Issue number6
DOIs
Publication statusPublished - Jul 2007

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Liver Transplantation
Hepatocellular Carcinoma
Fibrosis
Liver
Therapeutics
Disease-Free Survival
Survival Rate
Recurrence
Bleeding Time
Operative Time
Liver Cirrhosis
Intensive Care Units
Length of Stay

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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First-Line Liver Resection and Salvage Liver Transplantation Are Increasing Therapeutic Strategies for Patients With Hepatocellular Carcinoma and Child A Cirrhosis. / Vennarecci, G.; Ettorre, G. M.; Antonini, M.; Santoro, R.; Maritti, M.; Tacconi, G.; Spoletini, D.; Tessitore, L.; Perracchio, L.; Visco, G.; Puoti, C.; Santoro, E.

In: Transplantation Proceedings, Vol. 39, No. 6, 07.2007, p. 1857-1860.

Research output: Contribution to journalArticle

Vennarecci, G. ; Ettorre, G. M. ; Antonini, M. ; Santoro, R. ; Maritti, M. ; Tacconi, G. ; Spoletini, D. ; Tessitore, L. ; Perracchio, L. ; Visco, G. ; Puoti, C. ; Santoro, E. / First-Line Liver Resection and Salvage Liver Transplantation Are Increasing Therapeutic Strategies for Patients With Hepatocellular Carcinoma and Child A Cirrhosis. In: Transplantation Proceedings. 2007 ; Vol. 39, No. 6. pp. 1857-1860.
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title = "First-Line Liver Resection and Salvage Liver Transplantation Are Increasing Therapeutic Strategies for Patients With Hepatocellular Carcinoma and Child A Cirrhosis",
abstract = "Aim: The present study focused on nine patients with hepatocellular carcinoma (HCC) associated with Child A liver cirrhosis undergoing first-line liver resection and salvage liver transplantation (SLT) for liver tumor recurrence. Patients and methods: Forty-six patients with HCC underwent liver transplantation (OLT); 37 (80.5{\%}) were primary liver transplantations (PLTs) and 9 (19.5{\%}) were SLTs. All patients who underwent SLT received minor transabdominal liver resections. Results: The posttransplant 1-, 3-, and 5-year overall survival rates for SLT (88.9{\%}, 88.9{\%}, and 88.9{\%}) were similar to those for PLT (78{\%}, 62.7{\%}, and 62.7{\%}). Four (10.8{\%}) patients in the PLT group had HCC recurrence, while there was zero recurrence in the SLT group. The 1-, 3-, 5-year disease-free survival rates for PLT (89{\%}, 74{\%}, and 74{\%}) were similar to those for SLT (100{\%}, 100{\%}, and 100{\%}). The 1-, 3-, 5-year disease-free survival rates after PLT were 89{\%}, 74{\%}, and 74{\%}, and after SLT were 100{\%}, 100{\%}, and 100{\%}, respectively. The operative mortality, intraperioperative bleeding, operative time, intensive care unit stay, in-hospital stay, and overall incidence of postoperative complications were similar in the two groups. Conclusions: In our experience, SLT for HCC is a feasible procedure with similar results in terms of overall survival, disease-free survival, and postoperative complications to those reported for patients who underwent PLT at our institute. An important role exists for SLT as shown by the fact that such a strategy has been used in the 20{\%} of the patients undergoing OLT for HCC.",
author = "G. Vennarecci and Ettorre, {G. M.} and M. Antonini and R. Santoro and M. Maritti and G. Tacconi and D. Spoletini and L. Tessitore and L. Perracchio and G. Visco and C. Puoti and E. Santoro",
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T1 - First-Line Liver Resection and Salvage Liver Transplantation Are Increasing Therapeutic Strategies for Patients With Hepatocellular Carcinoma and Child A Cirrhosis

AU - Vennarecci, G.

AU - Ettorre, G. M.

AU - Antonini, M.

AU - Santoro, R.

AU - Maritti, M.

AU - Tacconi, G.

AU - Spoletini, D.

AU - Tessitore, L.

AU - Perracchio, L.

AU - Visco, G.

AU - Puoti, C.

AU - Santoro, E.

PY - 2007/7

Y1 - 2007/7

N2 - Aim: The present study focused on nine patients with hepatocellular carcinoma (HCC) associated with Child A liver cirrhosis undergoing first-line liver resection and salvage liver transplantation (SLT) for liver tumor recurrence. Patients and methods: Forty-six patients with HCC underwent liver transplantation (OLT); 37 (80.5%) were primary liver transplantations (PLTs) and 9 (19.5%) were SLTs. All patients who underwent SLT received minor transabdominal liver resections. Results: The posttransplant 1-, 3-, and 5-year overall survival rates for SLT (88.9%, 88.9%, and 88.9%) were similar to those for PLT (78%, 62.7%, and 62.7%). Four (10.8%) patients in the PLT group had HCC recurrence, while there was zero recurrence in the SLT group. The 1-, 3-, 5-year disease-free survival rates for PLT (89%, 74%, and 74%) were similar to those for SLT (100%, 100%, and 100%). The 1-, 3-, 5-year disease-free survival rates after PLT were 89%, 74%, and 74%, and after SLT were 100%, 100%, and 100%, respectively. The operative mortality, intraperioperative bleeding, operative time, intensive care unit stay, in-hospital stay, and overall incidence of postoperative complications were similar in the two groups. Conclusions: In our experience, SLT for HCC is a feasible procedure with similar results in terms of overall survival, disease-free survival, and postoperative complications to those reported for patients who underwent PLT at our institute. An important role exists for SLT as shown by the fact that such a strategy has been used in the 20% of the patients undergoing OLT for HCC.

AB - Aim: The present study focused on nine patients with hepatocellular carcinoma (HCC) associated with Child A liver cirrhosis undergoing first-line liver resection and salvage liver transplantation (SLT) for liver tumor recurrence. Patients and methods: Forty-six patients with HCC underwent liver transplantation (OLT); 37 (80.5%) were primary liver transplantations (PLTs) and 9 (19.5%) were SLTs. All patients who underwent SLT received minor transabdominal liver resections. Results: The posttransplant 1-, 3-, and 5-year overall survival rates for SLT (88.9%, 88.9%, and 88.9%) were similar to those for PLT (78%, 62.7%, and 62.7%). Four (10.8%) patients in the PLT group had HCC recurrence, while there was zero recurrence in the SLT group. The 1-, 3-, 5-year disease-free survival rates for PLT (89%, 74%, and 74%) were similar to those for SLT (100%, 100%, and 100%). The 1-, 3-, 5-year disease-free survival rates after PLT were 89%, 74%, and 74%, and after SLT were 100%, 100%, and 100%, respectively. The operative mortality, intraperioperative bleeding, operative time, intensive care unit stay, in-hospital stay, and overall incidence of postoperative complications were similar in the two groups. Conclusions: In our experience, SLT for HCC is a feasible procedure with similar results in terms of overall survival, disease-free survival, and postoperative complications to those reported for patients who underwent PLT at our institute. An important role exists for SLT as shown by the fact that such a strategy has been used in the 20% of the patients undergoing OLT for HCC.

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