First reported chikungunya fever outbreak in the republic of Congo, 2011

Nanikaly Moyen, Simon Djamel Thiberville, Boris Pastorino, Antoine Nougairede, Laurence Thirion, Jean Vivien Mombouli, Yannick Dimi, Isabelle Leparc-Goffart, Maria Rosaria Capobianchi, Amelia Dzia Lepfoundzou, Xavier De Lamballerie

Research output: Contribution to journalArticle

Abstract

Background: Chikungunya is an Aedes -borne disease characterised by febrile arthralgia and responsible for massive outbreaks. We present a prospective clinical cohort study and a retrospective serological study relating to a CHIK outbreak, in the Republic of Congo in 2011. Methodology and Findings: We analysed 317 suspected cases, of which 308 (97.2%) lived in the city of Brazzaville (66.6% in the South area). Amongst them, 37 (11.7%) were CHIKV+ve patients (i.e., biologically confirmed by a real-time RT-PCR assay), of whom 36 (97.3%) had fever, 22 (66.7%) myalgia and 32 (86.5%) arthralgia. All tested negative for dengue. The distribution of incident cases within Brazzaville districts was compared with CHIKV seroprevalence before the outbreak (34.4% in 517 blood donors), providing evidence for previous circulation of CHIKV. We applied a CHIK clinical score to 126 patients recruited within the two first day of illness (including 28 CHIKV+ves (22.2%)) with sensitivity (78.6%) and specificity (72.4%) values comparing with those of the referent study in Reunion Island. The negative predictive value was high (92%), but the positive predictive value (45%) indicate poor potential contribution to medical practice to identify CHIKV+ve patients in low prevalence outbreaks. However, the score allowed a slightly more accurate follow-up of the evolution of the outbreak than the criterion "fever+arthralgia". The complete sequencing of a Congolase isolate (Brazza-MRS1) demonstrated belonging to the East/Central/South African lineage and was further used for producing a robust genome-scale CHIKV phylogenetic analysis. Conclusions/Significance: We describe the first Chikungunya outbreak declared in the Republic of Congo. The seroprevalence study conducted amongst blood donors before outbreak provided evidence for previous CHIKV circulation. We suggest that a more systematic survey of the entomological situation and of arbovirus circulation is necessary in Central Africa for better understanding the environmental, microbiological and sociological determinants of emergence.

Original languageEnglish
Article numbere115938
JournalPLoS One
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 26 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'First reported chikungunya fever outbreak in the republic of Congo, 2011'. Together they form a unique fingerprint.

  • Cite this

    Moyen, N., Thiberville, S. D., Pastorino, B., Nougairede, A., Thirion, L., Mombouli, J. V., Dimi, Y., Leparc-Goffart, I., Capobianchi, M. R., Lepfoundzou, A. D., & De Lamballerie, X. (2014). First reported chikungunya fever outbreak in the republic of Congo, 2011. PLoS One, 9(12), [e115938]. https://doi.org/10.1371/journal.pone.0115938