FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions

Roberta La Starza; Barbara Crescenzi; Valeria Nofrini; Gianluca Barba; Caterina Matteucci; Lucia Brandimarte; Valentina Pierini; Nicoletta Testoni; Pellegrino Musto; Stefania Paolini; Valentina Gianfelici; Clelia T. Storlazzi; Antonio Pierini; Laura Berchicci; Paolo Gorello; Cristina Mecucci

doi:10.1016/j.leukres.2011.08.004

FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions

Roberta La Starza, Barbara Crescenzi, Valeria Nofrini, Gianluca Barba, Caterina Matteucci, Lucia Brandimarte, Valentina Pierini, Nicoletta Testoni, Pellegrino Musto, Stefania Paolini, Valentina Gianfelici, Clelia T. Storlazzi, Antonio Pierini, Laura Berchicci, Paolo Gorello, Cristina Mecucci

IRCCS Centro di Riferimento Oncologico della Basilicata (CROB)

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2_del) in 20/418 cases (4.7%). TET2_del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2_del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2_del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).

Original language	English
Pages (from-to)	37-41
Number of pages	5
Journal	Leukemia Research
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2011.08.004
Publication status	Published - Jan 2012

Keywords

-7/7q-
5q-
Del(4)(q24)
TET2 gene

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/j.leukres.2011.08.004

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La Starza, R., Crescenzi, B., Nofrini, V., Barba, G., Matteucci, C., Brandimarte, L., Pierini, V., Testoni, N., Musto, P., Paolini, S., Gianfelici, V., Storlazzi, C. T., Pierini, A., Berchicci, L., Gorello, P., & Mecucci, C. (2012). FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions. Leukemia Research, 36(1), 37-41. https://doi.org/10.1016/j.leukres.2011.08.004

La Starza, R, Crescenzi, B, Nofrini, V, Barba, G, Matteucci, C, Brandimarte, L, Pierini, V, Testoni, N, Musto, P, Paolini, S, Gianfelici, V, Storlazzi, CT, Pierini, A, Berchicci, L, Gorello, P & Mecucci, C 2012, 'FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions', Leukemia Research, vol. 36, no. 1, pp. 37-41. https://doi.org/10.1016/j.leukres.2011.08.004

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title = "FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions",

abstract = "We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2del) in 20/418 cases (4.7%). TET2del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).",

keywords = "-7/7q-, 5q-, Del(4)(q24), TET2 gene",

author = "{La Starza}, Roberta and Barbara Crescenzi and Valeria Nofrini and Gianluca Barba and Caterina Matteucci and Lucia Brandimarte and Valentina Pierini and Nicoletta Testoni and Pellegrino Musto and Stefania Paolini and Valentina Gianfelici and Storlazzi, {Clelia T.} and Antonio Pierini and Laura Berchicci and Paolo Gorello and Cristina Mecucci",

year = "2012",

month = jan,

doi = "10.1016/j.leukres.2011.08.004",

language = "English",

volume = "36",

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T1 - FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions

AU - La Starza, Roberta

AU - Crescenzi, Barbara

AU - Nofrini, Valeria

AU - Barba, Gianluca

AU - Matteucci, Caterina

AU - Brandimarte, Lucia

AU - Pierini, Valentina

AU - Testoni, Nicoletta

AU - Musto, Pellegrino

AU - Paolini, Stefania

AU - Gianfelici, Valentina

AU - Storlazzi, Clelia T.

AU - Pierini, Antonio

AU - Berchicci, Laura

AU - Gorello, Paolo

AU - Mecucci, Cristina

PY - 2012/1

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N2 - We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2del) in 20/418 cases (4.7%). TET2del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).

AB - We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2del) in 20/418 cases (4.7%). TET2del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).

KW - -7/7q-

KW - 5q-

KW - Del(4)(q24)

KW - TET2 gene

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FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions

Abstract

Keywords

ASJC Scopus subject areas

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