Abstract
We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2del) in 20/418 cases (4.7%). TET2del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).
Original language | English |
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Pages (from-to) | 37-41 |
Number of pages | 5 |
Journal | Leukemia Research |
Volume | 36 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2012 |
Keywords
- -7/7q-
- 5q-
- Del(4)(q24)
- TET2 gene
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology