FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions

Roberta La Starza, Barbara Crescenzi, Valeria Nofrini, Gianluca Barba, Caterina Matteucci, Lucia Brandimarte, Valentina Pierini, Nicoletta Testoni, Pellegrino Musto, Stefania Paolini, Valentina Gianfelici, Clelia T. Storlazzi, Antonio Pierini, Laura Berchicci, Paolo Gorello, Cristina Mecucci

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2del) in 20/418 cases (4.7%). TET2del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalLeukemia Research
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • -7/7q-
  • 5q-
  • Del(4)(q24)
  • TET2 gene

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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