FISH characterization of t(8;12)(q12;p13) observed as the sole karyotypic anomaly in a myelodysplastic syndrome patient

Palma Finelli, Nicola S. Fracchiolla, Daniela Giardino, Giulietta Gottardi, Daniela Lambertenghi Deliliers, Agostino Cortelezzi, Lidia Larizza, Giorgio Lambertenghi Deliliers

Research output: Contribution to journalArticlepeer-review

Abstract

We report a t(8;12)(q12; p13) as the sole cytogenetic anomaly in a patient with a myelodysplastic syndrome (MDS). By means of FISH, we mapped the genomic region involved in the breakpoint (bkp) on both chromosomes. The 12p13 bkp mapped between markers WI-664 and WI-9218, immediately distal to the breakpoint cluster region frequently involved in hematological neoplasms targeted by y964C10. The 8q12 bkp (not yet investigated by FISH) was characterized and found to occur between markers WI-3263 and D8S524 within the region recognized by y874E10.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume130
Issue number1
DOIs
Publication statusPublished - Oct 1 2001

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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