Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Dagrun Engeset, Tonje Braaten, Birgit Teucher, Tilman Kühn, H. B. Bueno-de-Mesquita, Max Leenders, Antonio Agudo, Manuela M. Bergmann, Elisavet Valanou, Androniki Naska, Antonia Trichopoulou, Timothy J. Key, Francesca L. Crowe, Kim Overvad, Emily Sonestedt, Amalia Mattiello, Petra H. Peeters, Maria Wennberg, Jan Håkan Jansson, Marie Christine Boutron-RuaultLaure Dossus, Laureen Dartois, Kuanrong Li, Aurelio Barricarte, Heather Ward, Elio Riboli, Claudia Agnoli, José María Huerta, María José Sánchez, Rosario Tumino, Jone M. Altzibar, Paolo Vineis, Giovanna Masala, Pietro Ferrari, David C. Muller, Mattias Johansson, M. Luisa Redondo, Anne Tjønneland, Anja Olsen, Karina Standahl Olsen, Magritt Brustad, Guri Skeie, Eiliv Lund

Research output: Contribution to journalArticlepeer-review


Fish is a source of important nutrients and may play a role in preventing heart diseases and other health outcomes. However, studies of overall mortality and cause-specific mortality related to fish consumption are inconclusive. We examined the rate of overall mortality, as well as mortality from ischaemic heart disease and cancer in relation to the intake of total fish, lean fish, and fatty fish in a large prospective cohort including ten European countries. More than 500,000 men and women completed a dietary questionnaire in 1992–1999 and were followed up for mortality until the end of 2010. 32,587 persons were reported dead since enrolment. Hazard ratios and their 99 % confidence interval were estimated using Cox proportional hazard regression models. Fish consumption was examined using quintiles based on reported consumption, using moderate fish consumption (third quintile) as reference, and as continuous variables, using increments of 10 g/day. All analyses were adjusted for possible confounders. No association was seen for fish consumption and overall or cause-specific mortality for both the categorical and the continuous analyses, but there seemed to be a U-shaped trend (p 

Original languageEnglish
Pages (from-to)57-70
Number of pages14
JournalEuropean Journal of Epidemiology
Issue number1
Publication statusPublished - 2015


  • Cohort
  • Fatty fish
  • Fish consumption
  • Lean fish
  • Mortality
  • Multi-centre study

ASJC Scopus subject areas

  • Epidemiology


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