Fish immunology. I. Binding and engulfment of Candida albicans by erythrocytes of rainbow trout (Salmo gairdneri Richardson)

L. Passantino, M. Altamura, A. Cianciotta, R. Patruno, A. Tafaro, E. Jirillo, G. F. Passantino

Research output: Contribution to journalArticlepeer-review

Abstract

The role of fish erythrocytes (FE) as phagocytic cells has poorly been investigated, until now. Here, we have focussed our attention on the interplay between rainbow trout (Salmo gairdneri Richardson) erythrocytes and Candida albicans (CA). At the same time, the intervention of autologous head kidney macrophages (MØ) in the CA processing by FE has been studied. Data show that CA particles bind to FE, which, in turn, are able to engulf but not kill them. In the presence of MØ, a decrease of FE with bound CA occurs and, in some microscopic images, FE form rosettes with MØ. Phagocytosis of CA is higher in rosetting MØ than in non-rosetting ones. According to our findings, it appears that FE represent a reservoir of engulfed CA and rosetting is an efficacious phenomenon of presentation of pathogens to MO, where an effective clearance of them can take place.

Original languageEnglish
Pages (from-to)665-678
Number of pages14
JournalImmunopharmacology and Immunotoxicology
Volume24
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Erythrocytes
  • Fish
  • Immunology

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Immunology
  • Pharmacology
  • Toxicology

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