TY - JOUR
T1 - Fish immunology. I. Binding and engulfment of Candida albicans by erythrocytes of rainbow trout (Salmo gairdneri Richardson)
AU - Passantino, L.
AU - Altamura, M.
AU - Cianciotta, A.
AU - Patruno, R.
AU - Tafaro, A.
AU - Jirillo, E.
AU - Passantino, G. F.
PY - 2002
Y1 - 2002
N2 - The role of fish erythrocytes (FE) as phagocytic cells has poorly been investigated, until now. Here, we have focussed our attention on the interplay between rainbow trout (Salmo gairdneri Richardson) erythrocytes and Candida albicans (CA). At the same time, the intervention of autologous head kidney macrophages (MØ) in the CA processing by FE has been studied. Data show that CA particles bind to FE, which, in turn, are able to engulf but not kill them. In the presence of MØ, a decrease of FE with bound CA occurs and, in some microscopic images, FE form rosettes with MØ. Phagocytosis of CA is higher in rosetting MØ than in non-rosetting ones. According to our findings, it appears that FE represent a reservoir of engulfed CA and rosetting is an efficacious phenomenon of presentation of pathogens to MO, where an effective clearance of them can take place.
AB - The role of fish erythrocytes (FE) as phagocytic cells has poorly been investigated, until now. Here, we have focussed our attention on the interplay between rainbow trout (Salmo gairdneri Richardson) erythrocytes and Candida albicans (CA). At the same time, the intervention of autologous head kidney macrophages (MØ) in the CA processing by FE has been studied. Data show that CA particles bind to FE, which, in turn, are able to engulf but not kill them. In the presence of MØ, a decrease of FE with bound CA occurs and, in some microscopic images, FE form rosettes with MØ. Phagocytosis of CA is higher in rosetting MØ than in non-rosetting ones. According to our findings, it appears that FE represent a reservoir of engulfed CA and rosetting is an efficacious phenomenon of presentation of pathogens to MO, where an effective clearance of them can take place.
KW - Erythrocytes
KW - Fish
KW - Immunology
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U2 - 10.1081/IPH-120016050
DO - 10.1081/IPH-120016050
M3 - Article
C2 - 12510797
AN - SCOPUS:12244279993
VL - 24
SP - 665
EP - 678
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
SN - 0892-3973
IS - 4
ER -