TY - JOUR
T1 - Fish intake is associated with lower cardiovascular risk in a Mediterranean population
T2 - Prospective results from the Moli-sani study
AU - Bonaccio, M.
AU - Ruggiero, E.
AU - Di Castelnuovo, A.
AU - Costanzo, S.
AU - Persichillo, M.
AU - De Curtis, A.
AU - Cerletti, C.
AU - Donati, M. B.
AU - de Gaetano, G.
AU - Iacoviello, L.
AU - Iacoviello, L.
AU - Donati, M. B.
AU - de Gaetano, G.
AU - Vermylen, J.
AU - De Paula Carrasco, I.
AU - Giampaoli, S.
AU - Spagnuolo, A.
AU - Assanelli, D.
AU - Centritto, V.
AU - Spagnuolo, P.
AU - Staniscia, D.
AU - Zito, F.
AU - Bonanni, A.
AU - Cerletti, C.
AU - De Curtis, A.
AU - Di Castelnuovo, A.
AU - Lorenzet, R.
AU - Mascioli, A.
AU - Olivieri, M.
AU - Rotilio, D.
AU - Bonaccio, M.
AU - Costanzo, S.
AU - Gianfagna, F.
AU - Giacci, M.
AU - Padulo, A.
AU - Petraroia, D.
AU - Magnacca, S.
AU - Marracino, F.
AU - Spinelli, M.
AU - Silvestri, C.
AU - dell'Elba, G.
AU - Grippi, C.
AU - De Lucia, F.
AU - Vohnout, B.
AU - Zito, F.
AU - Persichillo, M.
AU - Arcari, A.
AU - Cugino, D.
AU - Ferri, A.
AU - Mignogna, M.
AU - Moli-sani study Investigators
AU - Moli-sani study Investigators
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Background and aims Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet. Methods and results Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005–2010). Food intake was recorded by the Italian version of the EPIC food frequency questionnaire. Hazard ratios were calculated by using multivariable Cox-proportional hazard models. During a median follow-up of 4.3 years, a total of 352 events occurred (n of CHD = 287 and n of stroke = 66). After adjustment for a large panel of covariates, fish intake ≥4 times per week was associated with 40% reduced risk of composite CHD and stroke (HR = 0.60; 95%CI 0.40–0.90), and with 40% lower risk of CHD (HR = 0.60; 95%CI 0.38–0.94) as compared with subjects in the lowest category of intake (<2 times/week). A similar trend of protection was found for stroke risk although results were not significant (HR = 0.62; 95%CI 0.26–1.51). When fish types were considered, protection against the composite outcome and CHD was confined to fatty fish intake. Conclusions Fish intake was associated with reduced risk of composite fatal and non-fatal CHD and stroke in a general Mediterranean population. The favourable association was likely to be driven by fatty fish.
AB - Background and aims Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet. Methods and results Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005–2010). Food intake was recorded by the Italian version of the EPIC food frequency questionnaire. Hazard ratios were calculated by using multivariable Cox-proportional hazard models. During a median follow-up of 4.3 years, a total of 352 events occurred (n of CHD = 287 and n of stroke = 66). After adjustment for a large panel of covariates, fish intake ≥4 times per week was associated with 40% reduced risk of composite CHD and stroke (HR = 0.60; 95%CI 0.40–0.90), and with 40% lower risk of CHD (HR = 0.60; 95%CI 0.38–0.94) as compared with subjects in the lowest category of intake (<2 times/week). A similar trend of protection was found for stroke risk although results were not significant (HR = 0.62; 95%CI 0.26–1.51). When fish types were considered, protection against the composite outcome and CHD was confined to fatty fish intake. Conclusions Fish intake was associated with reduced risk of composite fatal and non-fatal CHD and stroke in a general Mediterranean population. The favourable association was likely to be driven by fatty fish.
KW - Cardiovascular risk
KW - Cerebrovascular events
KW - Coronary heart disease
KW - Fatty fish
KW - Fish intake
KW - Stroke
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UR - http://www.scopus.com/inward/citedby.url?scp=85030026769&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2017.08.004
DO - 10.1016/j.numecd.2017.08.004
M3 - Article
C2 - 28967596
AN - SCOPUS:85030026769
VL - 27
SP - 865
EP - 873
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 10
ER -